Results 111 to 113 of about 2,420 (113)

Synthesis and Biological Evaluation of New Creatine Fatty Esters Revealed Dodecyl Creatine Ester as a Promising Drug Candidate for the Treatment of the Creatine Transporter Deficiency

Journal of Medicinal Chemistry, 2013
The creatine transporter deficiency is a neurological disease caused by impairment of the creatine transporter SLC6A8, resulting in mental retardation associated with a complete absence of creatine within the brain and cellular energy perturbation of neuronal cells.
Alexandra, Trotier-Faurion, Sophie, Dézard, Frédéric, Taran, Vassili, Valayannopoulos, Pascale, de Lonlay, Aloïse, Mabondzo   +5 more
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Dodecyl creatine ester, a promising treatment to deliver creatine to neurons, achieves pharmacology efficacy in creatine transporter deficiency

European Journal of Medicinal Chemistry
Dodecyl creatine ester (DCE) is a creatine prodrug currently developed for brain diseases, including creatine transporter deficiency (CTD), an incurable rare genetic disease. A dual strategy combining a prodrug to bypass the non-functional creatine transporter and its delivery via the nose-to-brain pathway has been proposed to replenish creatine levels
Disdier, Clémence, Lhotellier, Clara, Guyot, Anne-Cécile, Costa, Narciso, Théodoro, Frédéric, Pruvost, Alain, Skelton, Matthew, Joudinaud, Thomas, Mabondzo, Aloïse, Bénech, Henri   +9 more
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Faculty Opinions recommendation of Synthesis and biological evaluation of new creatine fatty esters revealed dodecyl creatine ester as a promising drug candidate for the treatment of the creatine transporter deficiency.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2013
openaire   +1 more source