Results 31 to 40 of about 25,786 (177)

Plasma Proteomic Signatures for Alzheimer's Disease: Comparable Accuracy to ATN Biomarkers and Cross‐Platform Validation

Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 354-366, February 2026.
ABSTRACT Background There is growing recognition of the potential of plasma proteomics for Alzheimer's Disease (AD) risk assessment and disease characterization. However, differences between proteomics platforms introduce uncertainties regarding cross‐platform applicability.
Manyue Hu, Oliver Robinson, Christina M. Lill, Anna Matton, Raquel Puerta, Pilar Sanz, Merce Boada, Agustín Ruiz, Lefkos Middleton, for the Alzheimer's Disease Neuroimaging Initiative   +9 more
wiley   +1 more source

Soluble SORL1 in cerebrospinal fluid as a marker for functional impact of rare SORL1 variants

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION The sortilin‐related receptor (SORL1) directs APP and Aβ trafficking within the retromer pathway. Cleavage at the cell surface releases soluble SORL1 (sSORL1) into cerebrospinal fluid (CSF). We examined whether CSF‐sSORL1 can serve as an in vivo marker of genetically impaired SORL1.
Matthijs W. J. de Waal, Sven J. van der Lee, Melanie Lunding, Lynn Boonkamp, Nolan Barrett, Giulia Monti, Anne Mette G. Jensen, Christian B. Vaegter, Jan Raska, Sona Cesnarikova, Jiri Sedmik, Calvin Trieu, Marjan M. Weiss, Rosalina van Spaendonk, Lisa Vermunt, Georgii Ozhegov, Niccolo Tesi, Marc Hulsman, Dovile Januliene, Arne Moller, Dasa Bohaciakova, Wiesje M. van der Flier, Olav M. Andersen, Charlotte E. Teunissen, Henne Holstege   +24 more
wiley   +1 more source

Locus coeruleus‐entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Pretangle tau inclusions from the locus coeruleus (LC) are hypothesized to propagate to the entorhinal cortex (EC) via neuron‐to‐neuron transmission along its projections. The lower integrity of the LC‐EC pathway accompanying Alzheimer's disease (AD) pathology is supported by post mortem studies, but in vivo evidence remains ...
Yuliya Patsyuk, Maxime Van Egroo, Elise Beckers, Elouise A. Koops, Nicholas J. Ashton, Shorena Janelidze, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Benedikt A. Poser, Heidi I. L. Jacobs   +10 more
wiley   +1 more source

Detection of TDP‐43 seeds in CSF of presymptomatic and symptomatic genetic FTD/ALS

Alzheimer's &Dementia, Volume 21, Issue 12, December 2025.
Abstract INTRODUCTION Seed amplification assays (SAAs) have shown promising results in detecting misfolded transactive response (TAR) DNA‐binding protein 43 (TDP‐43) in cerebrospinal fluid (CSF) of genetic frontotemporal dementia (FTD). To date, the use of SAA has yet to be evaluated in presymptomatic individuals.
Ilaria Linda Dellarole, Vittoria Aprea, Marcella Catania, Claudia Battipaglia, Aurora Romeo, Cristina Villa, Anna Burato, Luigi Celauro, Eleonora Dalla Bella, Nilo Riva, Erika Salvi, Giacomina Rossi, Giuseppe Di Fede, Giuseppe Legname, Julie F H De Houwer, Antonella Alberici, Barbara Borroni, Harro Seelaar, John C van Swieten, Fabio Moda, Paola Caroppo   +20 more
wiley   +1 more source

Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
Elevated homocysteine results from genetic variants, impaired one‐carbon metabolism, nutritional deficiencies, and metabolic disorders. Hyperhomocysteinemia drives oxidative stress, inflammation, excitotoxicity, and epigenetic disruption, affecting multiple organs and systems.
Osmar Vieira Ramires Júnior, Gustavo Ricardo Krupp Prauchner, Alessandra Schmitt Rieder, Ana Karla Oliveira Leite, Clarissa Penha Farias, Angela T. S. Wyse   +5 more
wiley   +1 more source

The Global Impact of COVID‐19 Control Measures on People With Dementia Living at Home and Their Carers: A Systematic Review of Quantitative and Qualitative Research Across 27 Countries

Brain and Behavior, Volume 15, Issue 11, November 2025.
This graphical abstract summarizes the main findings of our systematic review about the global impacts of COVID‐19 control measures on people with dementia living at home and their carers : they were broadly consistent across regions. Our evidence synthesis highlights the critical need for decision‐makers to account for the needs of PWD and their ...
Yaohua Chen, Tatyana Mollayeva, Rachael Fitzpatrick, Thaisa Tylinski Sant'Ana, Francesca Farina, Dorota Swiatek, Kelli Sopidou, Evelyn Tabilo, Marta Betka, Iracema Leroi, Tomas Leon, Geeske Peeters, the STRAP consortium   +12 more
wiley   +1 more source

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

Acta Ophthalmologica, Volume 103, Issue 7, Page e511-e523, November 2025.
Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi, Niko Huotari, Ville Saarela, Marja Honkamo, Lauri Raitamaa, Vesa Korhonen, Johanna Tuunanen, Janne Kananen, Vesa Kiviniemi   +8 more
wiley   +1 more source

A RELAÇÃO ENTRE A PRIVAÇÃO DO SONO E A DOENÇA DE ALZHEIMER: UMA REVISÃO INTEGRATIVA

Arquivos de Ciências da Saúde da UNIPAR, 2023
Introdução: A privação de sono participa de diversos processos neuropatológicos, inclusive na fisiopatologia da Doença de Alzheimer, demência progressiva e multifatorial com morbimortalidade crescente.
Fillipe Silva Tourinho, Gabriel Vinícius Rodrigues da Silva, Giovanni Tessarine Barbosa Bologna, Breno Casellatto Rodrigues Almeida, João Pedro Gontijo Andrade, Samuel Lopes Toledo, Evelise Aline Soares, Gema Galgani de Mesquita Duarte   +7 more
doaj   +1 more source

Uso de anticolinesterásicos na doença de Alzheimer

Debates em Psiquiatria, 2015
A doença de Alzheimer (DA) é a causa mais comum de demência, caracterizada por início insidioso e curso progressivo, com declínio cognitivo, comprometimento da autonomia e da capacidade de realização de atividades de vida diária, alterações de humor e ...
Kellen Klein Pereira, Valeska Marinho Rodrigues   +1 more
doaj   +1 more source

The impact of cognitive, functional, and mobility decline of elderly with Alzheimer disease on their caregivers' burden [PDF]

, 2009
O objetivo foi avaliar capacidade funcional, mobilidade e função cognitiva de idosos com a doença de Alzheimer (DA), bem como o nível de sobrecarga de seus cuidadores, verificando possíveis associações entre essas variáveis. Foram selecionados 28 idosos (
Albuquerque, Cristina Rodrigues, Borges, Larissa de Lima, Garcia, Patrícia Azevedo   +2 more
core   +3 more sources