Results 11 to 20 of about 159,699 (232)

Oral transmission of Chagas disease from a One Health approach: A systematic review

Tropical Medicine &International Health, Volume 28, Issue 9, Page 689-698, September 2023., 2023
Abstract Objective To analyse acute Chagas disease (CD) outbreaks through a qualitative systematic review and discuss the determinants for its prevention and control. Methods Review of studies in which clinical cases of oral transmission were confirmed by parasitological and/or serological tests that included an epidemiological investigation of sources
Alejandra López‐García, Juan A. Gilabert   +1 more
wiley   +1 more source

Senescent T cells: Beneficial and detrimental roles

Immunological Reviews, Volume 316, Issue 1, Page 160-175, July 2023., 2023
Summary As the thymus involutes during aging, the T‐cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward replicative senescence, due to telomere erosion.
Phatthamon Laphanuwat, Daniel Claudio Oliveira Gomes, Arne N. Akbar   +2 more
wiley   +1 more source

Suppression of TGF‐β/Smad2 signaling by GW788388 enhances DENV‐2 clearance in macrophages

Journal of Medical Virology, Volume 94, Issue 9, Page 4359-4368, September 2022., 2022
Abstract Dengue fever, caused by the dengue virus (DENV‐1, −2, −3, and −4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue is correlated with high viraemia and cytokine storm, such as high levels of transforming growth factor‐β1 (TGF‐β1) in the patient's serum.
Gabrielly Sbano Teixeira, Audrien Alves Andrade, Lauana Ribas Torres, Dinair Couto‐Lima, Otacilio C. Moreira, Rayane Abreu, Mariana Caldas Waghabi, Elen Mello de Souza   +7 more
wiley   +1 more source

Effects of anti‐Leishmania compounds in the behavior of the sand fly vector Lutzomyia longipalpis

Pest Management Science, Volume 78, Issue 7, Page 2792-2805, July 2022., 2022
Sugar baits can be used to block the development of Leishmania parasites inside the gut of the vector, adult female sand flies. In this work, we screened a series of synthetic compounds and showed that three of them are suitable for the future development of baits targeting the Leishmania parasites inside the sand fly Lutzomyia longipalpis.
Tainá Neves Ferreira, Reginaldo Peçanha Brazil, Mary Ann McDowell, Edézio Ferreira Cunha‐Júnior, Paulo Roberto Ribeiro Costa, Chaquip Daher Netto, Eduardo Caio Torres Santos, Fernando Ariel Genta   +7 more
wiley   +1 more source

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

Journal of Extracellular Vesicles, Volume 10, Issue 10, August 2021., 2021
Abstract Whereas extracellular vesicle (EV) research has become commonplace in different biomedical fields, this field of research is still in its infancy in mycology. Here we provide a robust set of data regarding the structural and compositional aspects of EVs isolated from the fungal pathogenic species Cryptococcus neoformans, C. deneoformans and C.
Juliana Rizzo, Sarah Sze Wah Wong, Anastasia D. Gazi, Frédérique Moyrand, Thibault Chaze, Pierre‐Henri Commere, Sophie Novault, Mariette Matondo, Gérard Péhau‐Arnaudet, Flavia C. G. Reis, Matthijn Vos, Lysangela R. Alves, Robin C. May, Leonardo Nimrichter, Marcio L. Rodrigues, Vishukumar Aimanianda, Guilhem Janbon   +16 more
wiley   +1 more source

Combining Well‐Tempered Metadynamics Simulation and SPR Assays to Characterize the Binding Mechanism of the Universal T‐Lymphocyte Tetanus Toxin Epitope TT830‐843

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Peptide TT830‐843 from the tetanus toxin is a universal T‐cell epitope. It helps in vaccination and induces T‐cell activation. However, the fine molecular interaction between this antigen and the major histocompatibility complex (MHC) remains unknown.
Artur A. M. L. Brandt, Rodrigo N. Rodrigues-da-Silva, Josué C. Lima-Junior, Carlos R. Alves, Franklin de Souza-Silva, Sebastien Fiorucci   +5 more
wiley   +1 more source

The role of senescent T cells in immunopathology

Aging Cell, Volume 19, Issue 12, December 2020., 2020
Senescence occurs in tissues as well as in the immune system but the interaction between this is poorly understood. Senescent T cells are pro‐inflammatory, express NK receptors that can act independent of the TCR, and are highly cytotoxic. They recognise stress ligands expressed by cells in inflamed or infected tissues or as a consequence of cellular ...
Luciana P. Covre, Roel P. H. De Maeyer, Daniel C. O. Gomes, Arne N. Akbar   +3 more
wiley   +1 more source

Zika Virus Infection Leads to Variable Defects in Multiple Neurological Functions and Behaviors in Mice and Children

Advanced Science, Volume 7, Issue 18, September 23, 2020., 2020
A spectrum of neurodevelopmental abnormalities is identified in children and neonatal mice with perinatal exposure to Zika virus (ZIKV), regardless of apparent abnormal brain structure. Thus, special attention should be paid to all children born to ZIKV infected mothers for screening of abnormal behaviors and sensory function during childhood ...
Ziqi Zhao, Ziwei Shang, Zilton Vasconcelos, Chunfeng Li, Yisheng Jiang, Shulong Zu, Jingyi Zhang, Fengchao Wang, Li Yao, Jae U. Jung, Patricia Brasil, Maria Elisabeth Moreira, Cheng‐Feng Qin, Tara Kerin, Karin Nielsen‐Saines, Genhong Cheng, Xiaohui Zhang, Zhiheng Xu   +17 more
wiley   +1 more source

Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study

Nutrition Journal, 2017
Background Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies.
Paula Simplício da Silva, Mauro Felippe Felix Mediano, Gilberto Marcelo Sperandio da Silva, Patricia Dias de Brito, Claudia Santos de Aguiar Cardoso, Cristiane Fonseca de Almeida, Luiz Henrique Conde Sangenis, Roberta Olmo Pinheiro, Alejandro Marcel Hasslocher-Moreno, Pedro Emmanuel Alvarenga Americano do Brasil, Andrea Silvestre de Sousa   +10 more
doaj   +1 more source

Microsatellite variation revealed panmictic pattern for Triatoma brasiliensis (Triatominae: Reduviidae) in rural northeastern Brazil: the control measures implications

BMC Genetics, 2020
Background Triatoma brasiliensis Neiva, 1911 is the main vector of Trypanosoma cruzi in the caatinga of Northeastern Brazil. Despite of its epidemiological relevance, there are few studies on its genetic variability.
Claudia Mendonça Bezerra, Carlota Josefovicz Belisário, Grasielle Caldas D’Ávilla Pessoa, Aline Cristine Luiz Rosa, Carla Patrícia Barezani, Flávio Campos Ferreira, Alberto Novaes Ramos, Ricardo Esteban Gürtler, Liléia Diotaiuti   +8 more
doaj   +1 more source