Results 11 to 20 of about 215,258 (243)

Why Treat Chronic Forms of Chagas Disease with Benznidazole if Adverse Reactions are Very Frequent? [PDF]

Arq Bras Cardiol
Hasslocher-Moreno AM.
europepmc   +2 more sources

Oral transmission of Chagas disease from a One Health approach: A systematic review

Tropical Medicine &International Health, Volume 28, Issue 9, Page 689-698, September 2023., 2023
Abstract Objective To analyse acute Chagas disease (CD) outbreaks through a qualitative systematic review and discuss the determinants for its prevention and control. Methods Review of studies in which clinical cases of oral transmission were confirmed by parasitological and/or serological tests that included an epidemiological investigation of sources
Alejandra López‐García, Juan A. Gilabert   +1 more
wiley   +1 more source

Senescent T cells: Beneficial and detrimental roles

Immunological Reviews, Volume 316, Issue 1, Page 160-175, July 2023., 2023
Summary As the thymus involutes during aging, the T‐cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward replicative senescence, due to telomere erosion.
Phatthamon Laphanuwat, Daniel Claudio Oliveira Gomes, Arne N. Akbar   +2 more
wiley   +1 more source

Suppression of TGF‐β/Smad2 signaling by GW788388 enhances DENV‐2 clearance in macrophages

Journal of Medical Virology, Volume 94, Issue 9, Page 4359-4368, September 2022., 2022
Abstract Dengue fever, caused by the dengue virus (DENV‐1, −2, −3, and −4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue is correlated with high viraemia and cytokine storm, such as high levels of transforming growth factor‐β1 (TGF‐β1) in the patient's serum.
Gabrielly Sbano Teixeira, Audrien Alves Andrade, Lauana Ribas Torres, Dinair Couto‐Lima, Otacilio C. Moreira, Rayane Abreu, Mariana Caldas Waghabi, Elen Mello de Souza   +7 more
wiley   +1 more source

Effects of anti‐Leishmania compounds in the behavior of the sand fly vector Lutzomyia longipalpis

Pest Management Science, Volume 78, Issue 7, Page 2792-2805, July 2022., 2022
Sugar baits can be used to block the development of Leishmania parasites inside the gut of the vector, adult female sand flies. In this work, we screened a series of synthetic compounds and showed that three of them are suitable for the future development of baits targeting the Leishmania parasites inside the sand fly Lutzomyia longipalpis.
Tainá Neves Ferreira, Reginaldo Peçanha Brazil, Mary Ann McDowell, Edézio Ferreira Cunha‐Júnior, Paulo Roberto Ribeiro Costa, Chaquip Daher Netto, Eduardo Caio Torres Santos, Fernando Ariel Genta   +7 more
wiley   +1 more source

Electrocardiographic Abnormalities and Treatment with Benznidazole among Children with Chronic Infection by Trypanosoma cruzi: A Retrospective Cohort Study [PDF]

, 2016
Background: Chronic infection by Trypanosoma cruzi could cause heart conduction disturbances. We sought to analyze electrocardiographic abnormalities among children with chronic T. cruzi infection with and without trypanocidal treatment with benznidazole.
Colantonio, Lisandro Damián, Prado, Nilda, Segura, Elsa Leonor, Sosa-Estani, Sergio Alejandro   +3 more
core   +7 more sources

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

Journal of Extracellular Vesicles, Volume 10, Issue 10, August 2021., 2021
Abstract Whereas extracellular vesicle (EV) research has become commonplace in different biomedical fields, this field of research is still in its infancy in mycology. Here we provide a robust set of data regarding the structural and compositional aspects of EVs isolated from the fungal pathogenic species Cryptococcus neoformans, C. deneoformans and C.
Juliana Rizzo, Sarah Sze Wah Wong, Anastasia D. Gazi, Frédérique Moyrand, Thibault Chaze, Pierre‐Henri Commere, Sophie Novault, Mariette Matondo, Gérard Péhau‐Arnaudet, Flavia C. G. Reis, Matthijn Vos, Lysangela R. Alves, Robin C. May, Leonardo Nimrichter, Marcio L. Rodrigues, Vishukumar Aimanianda, Guilhem Janbon   +16 more
wiley   +1 more source

Evaluation of Tpeak–Tend and QT intervals in Chagas’ Disease, Chronic Phase and Normal Electrocardiogram

Journal of Cardiac Arrhythmias, 2020
Introduction: Chagas’ disease lacks elements to predict which carriers will evolve into cardiac form and which will remain in undetermined form. Objective: To evaluate the relationship between electrocardiographic evolution and Tpeak–Tend and QT ...
Abilio Augusto Fragata Filho, Claudia da Silva Fragata, Angela Maria Lourenço, Cristiane Castro Faccini, João Ítalo Dias França   +4 more
doaj   +4 more sources

Combining Well‐Tempered Metadynamics Simulation and SPR Assays to Characterize the Binding Mechanism of the Universal T‐Lymphocyte Tetanus Toxin Epitope TT830‐843

BioMed Research International, Volume 2021, Issue 1, 2021., 2021
Peptide TT830‐843 from the tetanus toxin is a universal T‐cell epitope. It helps in vaccination and induces T‐cell activation. However, the fine molecular interaction between this antigen and the major histocompatibility complex (MHC) remains unknown.
Artur A. M. L. Brandt, Rodrigo N. Rodrigues-da-Silva, Josué C. Lima-Junior, Carlos R. Alves, Franklin de Souza-Silva, Sebastien Fiorucci   +5 more
wiley   +1 more source

Developmental and reproductive patterns of Triatoma brasiliensis infected with Trypanosoma cruzi under laboratory conditions

Memorias do Instituto Oswaldo Cruz, 2010
The aim of this work was to study the interaction between Trypanosoma cruzi-1 and Triatoma brasiliensis. A group of 1st instar nymphs was initially fed on T. cruzi-infected mice and a control group was fed on uninfected mice.
Tiago G Oliveira, Filipe A Carvalho-Costa, Taís F Gomes, Otília Sarquis, Ricardo Sposina, Marli M Lima   +5 more
doaj   +1 more source