Fatal CTLA‐4 heterozygosity with autoimmunity and recurrent infections: a de novo mutation [PDF]
Clinical Case Reports, 2017 Key Clinical Message Primary immunodeficiency disorders are rarely diagnosed in adults but must be considered in the differential diagnosis of combined recurrent infections and autoimmune disease.
Maria Francisca Moraes‐Fontes +9 more
doaj +3 more sources
Complex antiphospholipid syndrome successfully controlled for 17 years with personalized enoxaparin therapy [PDF]
European Journal of Case Reports in Internal MedicineAntiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by the presence of antiphospholipid antibodies and venous and arterial thrombotic events, including obstetric complications.
Mafalda Vasconcelos +4 more
doaj +2 more sources
Neurodegeneration in systemic lupus erythematosus: layer by layer retinal study using optical coherence tomography [PDF]
International Journal of Retina and Vitreous, 2020 Background Systemic lupus erythematosus (SLE) is a chronic, autoimmune and multisystemic disease. Recent studies with functional and structural magnetic resonance imaging and cognitive tests report an unexpectedly high frequency of central nervous system
Arnaldo Dias-Santos +7 more
doaj +2 more sources
Células T regulatórias naturais (T REGS) em doenças reumáticas Natural regulatory T cells in rheumatic diseases [PDF]
Revista Brasileira de Reumatologia, 2008 O sistema imune sadio deve manter o balanço entre a capacidade de responder a agentes infecciosos e de sustentar a autotolerância. A ausência de resposta adequada submete o indivíduo aos efeitos deletérios da invasão por patógenos, ao passo que o sistema
Wilson de Melo Cruvinel +5 more
doaj +4 more sources
Heterogeneous lupus-specific lesions and treatment outcome, in a single patient, over a period of time. [PDF]
Clin Case Rep, 2019 The report highlights the importance of strict clinico-histological correlations when skin biopsies are performed in diagnostic doubt in systemic lupus erythematosus.
Fernandes M +5 more
europepmc +4 more sources
Acta Médica Portuguesa, 2021 Introduction: Clinical outcomes in rheumatoid arthritis have greatly improved with therapeutic advances. Despite the availability of substantial clinical trial evidence, there is a lack of real-life data.
Melissa Fernandes +11 more
doaj +1 more source
Genetic and humoral autoimmunity markers of type 1 diabetes: from theory to practice [PDF]
, 2008 Type 1 A diabetes mellitus (T1AD) results from the autoimmune destruction of the insulin producing pancreatic beta-cells. The largest contribution to genetic susceptibility comes from several genes located in the major histocompatibility complex on ...
Davini, Elaine +2 more
core +5 more sources
Determinant Factors of Morbidity in Patients with Systemic Lupus Erythematosus
Acta Médica Portuguesa, 2017 Introduction: Severity in systemic lupus erythematosus may vary from mild to even fatal consequences. There are no biomarkers to predict the disease’s prognosis.
Margarida Jacinto +3 more
doaj +1 more source
Provas de atividade inflamatória no pênfigo foliáceo endêmico
Revista da Sociedade Brasileira de Medicina Tropical, 1994 O pênfigo foliáceo endêmico (PFE) é uma afecção onde fenômenos auto-imunes são freqüentemente relacionados com sua patogênese. Abordaram-se neste estudo, alguns testes laboratoriais freqüentemente alterados em outras doenças auto-imunes.
João Franquini Junior +5 more
doaj +3 more sources
Acta Médica Portuguesa, 2018 Introduction: Systemic sclerosis is a complex disorder that requires systematic screening. Our objective is to report the European Scleroderma Trials and Research group centre affiliation and its impact in our clinical practice. Material and Methods: The
Carolina Vidal +9 more
doaj +1 more source