Results 131 to 140 of about 1,332,137 (370)

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

Lessons Learned: Acting as Guardian/Special Master in the Bad Newz Kennels Case [PDF]

, 2008
The United States District Court for the Eastern District of Virginia appointed Rebecca Huss as the guardian/special master of the pit bulls that were the subject of the case against Michael Vick relating to dog fighting.
Huss, Rebecca J.
core   +1 more source

Successful medical management of an epidural abscess in a dog [PDF]

, 2017
A seven-month-old entire male dobermann presented with acute onset neck pain and left thoracic limb lameness. The dog had a similar episode eight weeks before presentation that responded to meloxicam.
Durand, Alexane, Gutierrez-Quintana, Rodrigo, Jose-Lopez, Roberto, Romero-Fernancez, Nora   +3 more
core   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Recognizing early MRI signs (or their absence) is crucial in diagnosing metachromatic leukodystrophy

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1999-2009, December 2022., 2022
Abstract Objectives Metachromatic leukodystrophy (MLD) has characteristic white matter (WM) changes on brain MRI, which often trigger biochemical and genetic confirmation of the diagnosis. In early or pre‐symptomatic disease stages, these typical MRI changes might be absent, hampering early diagnosis.
Daphne H. Schoenmakers, Shanice Beerepoot, Ingeborg Krägeloh‐Mann, Saskia Elgün, Benjamin Bender, Marjo S. van der Knaap, Nicole I. Wolf, Samuel Groeschel   +7 more
wiley   +1 more source

Multifunctional targeting micelle nanocarriers with both imaging and therapeutic potential for bladder cancer. [PDF]

, 2012
BackgroundWe previously developed a bladder cancer-specific ligand (PLZ4) that can specifically bind to both human and dog bladder cancer cells in vitro and in vivo. We have also developed a micelle nanocarrier drug-delivery system.
de Vere White, Ralph, Gao, Tingjuan, Lam, Kit S, Lara, Primo N, Li, Yuanpei, Lin, Tzu-Yin, Luo, Juntao, Pan, Chong-Xian, Zhang, Hongyong   +8 more
core   +2 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Potential mental health-related harms associated with the universal screening of anxiety and depressive symptoms in Australian secondary schools

Child and Adolescent Psychiatry and Mental Health
Background Anxiety and depressive disorders typically emerge in adolescence and can be chronic and disabling if not identified and treated early. School-based universal mental health screening may identify young people in need of mental health support ...
Taylor A. Braund, Simon T. E. Baker, Mirjana Subotic-Kerry, Gabriel Tillman, Nathan J. Evans, Andrew Mackinnon, Helen Christensen, Bridianne O’Dea   +7 more
doaj   +1 more source

The influence of prior experience and expected timing on vibrotactile discrimination

Frontiers in Neuroscience, 2013
Vibrotactile discrimination tasks involve perceptual judgements on stimulus pairs separated by a brief interstimulus interval (ISI). Despite their apparent simplicity, decision making during these tasks is biased by prior experience in a manner that is ...
Muhsin eKarim, Muhsin eKarim, Justin A Harris, Angela eLangdon, Angela eLangdon, Michael eBreakspear, Michael eBreakspear, Michael eBreakspear, Michael eBreakspear   +8 more
doaj   +1 more source