Results 121 to 130 of about 696,683 (349)

Jealousy of a Dog

Science, 1892
n ...
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Emergency department mental health presentations in bushfire-, flood-, storm-, drought-, and COVID-19-affected areas: Analysis of growth models between 2017 and 2021

Australian and New Zealand Journal of Public Health
Objective: Repeated exposure to adverse events increases the possibility of negative emotional consequences and the development of post-traumatic stress disorders. Communities who have faced several extreme weather events and pandemic-related disruptions
Samineh Sanatkar, Samuel B. Harvey, Andrew Mackinnon, Richard Bryant, Grant Sara   +4 more
doaj   +1 more source

Expectations for dog ownership: Perceived physical, mental and psychosocial health consequences among prospective adopters

PLoS ONE, 2018
Dog ownership is popular worldwide, with most human-dog dyads forming successful attachment bonds. However, millions of dogs are surrendered to animal shelters annually, possibly due to mismatches between owner expectations and the realities of dog ...
Lauren Powell, D. Chia, P. McGreevy, A. Podberscek, K. Edwards, Brendon Neilly, A. Guastella, Vanessa Lee, E. Stamatakis   +8 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stories with happy endings: Preventing pet dog attacks on children [PDF]

, 2008
A number of dog safety resources have been produced as a result of this research. Obtain a copy of the children’s leaflet (about 5-6yrs) in English from https://hdl.handle.net/10289/968.
Carter, Jennifer, Swain, David
core  

Identifying distinct service use phenotypes across levels of suicidality and self-harm: a UK Biobank study

npj Mental Health Research
Mental health service use among individuals experiencing suicidality and self-harm is highly variable, with many individuals not seeking professional help.
Biya Tang, Fiona Shand, Helen Christensen, Alexis E. Whitton   +3 more
doaj   +1 more source

Complex disease and phenotype mapping in the domestic dog

Nature Communications, 2016
The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date,
J. J. Hayward, M. Castelhano, Kyle C. Oliveira, E. Corey, C. Balkman, T. Baxter, Margret L. Casal, S. Center, Mei-Ying Fang, S. Garrison, S. Kalla, Pavel Korniliev, M. Kotlikoff, N. S. Moise, L. Shannon, K. Simpson, N. Sutter, R. Todhunter, A. Boyko   +18 more
semanticscholar   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Tapping into truth: an exploratory cross-sectional analysis of psychomotor symptoms and typing behaviour in an adolescent observational cohort

NPP-Digital Psychiatry and Neuroscience
Typing behaviour derived from smartphone keystroke metadata is an emerging digital phenotype that may assist in diagnosing and monitoring depressive symptoms.
Taylor A. Braund, Debopriyo Bal, Helen Christensen, Philip J. Batterham, Bojana Vilus, Kate Maston, Mark E. Larsen, Aliza Werner-Seidler, Kit Huckvale, Alexis E. Whitton, Gabriel Tillman, Bridianne O’Dea   +11 more
doaj   +1 more source