Results 101 to 110 of about 225,201 (268)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

How can school staff respond to student incidents of self-injurious thoughts and behaviours? A systematic scoping review

International Journal of Qualitative Studies on Health & Well-Being
Purpose Self-harm risk is highest between ages 12–19, making it essential for schools to have clear, evidence-based practices for identifying and responding to self-injurious thoughts and behaviours (SITBs).
Lauren McGillivray, Annabelle Hudson, Rachel Baffsky, Bridianne O'Dea, Michelle Torok   +4 more
doaj   +1 more source

Use of smartphone sensor data in detecting and predicting depression and anxiety in young people (12–25 years): A scoping review

Heliyon
Digital phenotyping is a promising method for advancing scalable detection and prediction methods in mental health research and practice. However, little is known about how digital phenotyping data are used to make inferences about youth mental health ...
Joanne R. Beames, Jin Han, Artur Shvetcov, Wu Yi Zheng, Aimy Slade, Omar Dabash, Jodie Rosenberg, Bridianne O'Dea, Suranga Kasturi, Leonard Hoon, Alexis E. Whitton, Helen Christensen, Jill M. Newby   +12 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Dog is Dog - a performance

, 2019
Rapport fra prosjektet Dog is Dog (2017-2018) Prosjektet er støttet av KUF-utvalget ved Kunsthøgskolen i ...
openaire   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Potential mental health-related harms associated with the universal screening of anxiety and depressive symptoms in Australian secondary schools

Child and Adolescent Psychiatry and Mental Health
Background Anxiety and depressive disorders typically emerge in adolescence and can be chronic and disabling if not identified and treated early. School-based universal mental health screening may identify young people in need of mental health support ...
Taylor A. Braund, Simon T. E. Baker, Mirjana Subotic-Kerry, Gabriel Tillman, Nathan J. Evans, Andrew Mackinnon, Helen Christensen, Bridianne O’Dea   +7 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

An assessment of the informativeness of clinical trials in digital mental health

npj Mental Health Research
Clinical trials in digital mental health have grown rapidly, yet little research has examined their informativeness. This study assessed the proportions of recent trials that met indicators of informativeness and explored related factors.
Bridianne O’Dea, Sally Rooke, Eliza-Rose Gordon, Fergus L. Lyons, Bojana Vilus, Neelesh Paravastu, Philip J. Batterham   +6 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source