Results 81 to 90 of about 1,631,669 (355)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Predictors of depression outcomes among university students following brief smartphone-based interventions

npj Mental Health Research
Smartphone-delivered interventions offer a scalable solution for university students experiencing depression, yet outcomes remain inconsistent. This study examined predictors of depression remission and response in the AI-enhanced Vibe Up adaptive trial ...
Xuanchen Liu, WuYi Zheng, Leonard Hoon, Sunil Gupta, Svetha Venkatesh, Helen Christensen, Jill Newby, Alexis E. Whitton, On behalf of the Vibe Up Trial Consortium   +8 more
doaj   +1 more source

Dog breed selection and factors that shape them : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Zoology at Massey University, Palmerston North, New Zealand [PDF]

, 2016
The aim of this research was to describe human perceptions of dog breeds, New Zealand national dog demographics, and the relationship between aesthetic appeal and physical conformation of dog breeds.
Challand, Tyler J
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Optimising the implementation of a universal web-based mental health service for Australian secondary schools: a cluster randomised controlled trial

Child and Adolescent Psychiatry and Mental Health
Background Secondary schools are increasingly delivering a range of mental health interventions with varied success. This trial examined the effectiveness of two implementation strategies, allocation of class time and provision of financial incentives ...
Mirjana Subotic-Kerry, Andrew Mackinnon, Dervla Gallen, Simon Baker, Belinda Louise Parker, Melinda Rose Achilles, Cassandra Chakouch, Nicole Cockayne, Helen Christensen, Bridianne O’Dea   +9 more
doaj   +1 more source

Rabies elimination research: juxtaposing optimism, pragmatism and realism [PDF]

, 2017
More than 100 years of research has now been conducted into the prevention, control and elimination of rabies with safe and highly efficacious vaccines developed for use in human and animal populations. Domestic dogs are a major reservoir for rabies, and
Bögel K, Cleaveland S, Debre P, Ferguson EA, Garside D, GBD, Hampson K, Harischandra LPA, King AA, Knobel D, Knobel DL, Pemberton N, Wandeler AI, Woodroffe R   +13 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source