Results 191 to 200 of about 1,332,137 (370)

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Effect of the LifeSpan suicide prevention model on self-harm and suicide in four communities in New South Wales, Australia: a stepped-wedge, cluster randomised controlled trial

BMJ Mental Health
Background There have been few rigorous evaluations of population, multi-strategy, suicide prevention programmes, despite increasing global recognition that such approaches are needed to reduce suicide.Objective To examine the effects of a multi-strategy
Helen Christensen, Michelle Torok, Matthew Phillips, Grant Sara, Andrew Page, Andrew Mackinnon, Henry Cutler, Alison L Calear, Isabel Zbukvic, Philip J Batterham, Lisa N Sharwood, Fiona Shand, Myfanwy Maple, Alexander Burnett, Brian Draper, Lauren McGillivray, Jiahui Qian, Stephanie Zeritis, Demee Rheinberger   +18 more
doaj   +1 more source

Combined atypical primary hypoadrenocorticism and primary hypothyroidism in a dog [PDF]

, 2016
A dog with combined atypical primary hypoadrenocorticism and primary hypothyroidism is described. The dog presented with waxing and waning, vague complaints since more than a year and had been treated with several drugs without complete resolution of ...
Binst, Dominique, Daminet, Sylvie, Martlé, Valentine, Paepe, Dominique, Smets, Pascale, Vanmal, Britt   +5 more
core  

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Pitch discrimination in the dog [PDF]

, 1920
G. V. Anrep
openalex   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

A web-based video messaging intervention for suicide prevention in men: study protocol for a five-armed randomised controlled trial

Trials
Background More than 50% of people who die by suicide have not been in contact with formal mental health services. The rate of people who fly ‘under the radar’ of mental health services is higher among men than women, indicating a need to improve ...
Jin Han, Aimy Slade, Hiroko Fujimoto, Wu Yi Zheng, Artur Shvetcov, Leonard Hoon, Joost Funke Kupper, Manisha Senadeera, Sunil Gupta, Svetha Venkatesh, Kon Mouzakis, Yuanyuan Gu, Anam Bilgrami, Noura Saba, Henry Cutler, Philip Batterham, Katherine Boydell, Fiona Shand, Alexis Whitton, Helen Christensen   +19 more
doaj   +1 more source

FURTHER OBSERVATIONS ON THE T WAVE OF THE ELECTROCARDIOGRAM OF THE DOG FOLLOWING THE LIGATION OF THE CORONARY ARTERIES [PDF]

, 1920
FRED M. SMITH
openalex   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Performance analysis of control allocation using data‐driven integral quadratic constraints

Advanced Control for Applications, Volume 4, Issue 4, December 2022., 2022
Abstract A new method is presented for evaluating the performance of a nonlinear control allocation system within a linear control loop. To that end, a worst‐case gain analysis problem is formulated that can be readily solved by means of well‐established methods from robustness analysis using integral quadratic constraints (IQCs).
Manuel Pusch, Daniel Ossmann, Harald Pfifer   +2 more
wiley   +1 more source