Results 51 to 60 of about 225,201 (268)

Optimising the implementation of a universal web-based mental health service for Australian secondary schools: a cluster randomised controlled trial

Child and Adolescent Psychiatry and Mental Health
Background Secondary schools are increasingly delivering a range of mental health interventions with varied success. This trial examined the effectiveness of two implementation strategies, allocation of class time and provision of financial incentives ...
Mirjana Subotic-Kerry, Andrew Mackinnon, Dervla Gallen, Simon Baker, Belinda Louise Parker, Melinda Rose Achilles, Cassandra Chakouch, Nicole Cockayne, Helen Christensen, Bridianne O’Dea   +9 more
doaj   +1 more source

Tackling burnout in Australian doctors by blending a web-based cognitive-behavioural therapy program with telehealth psychological support – protocol for a three-arm randomised-controlled trial

Contemporary Clinical Trials Communications
Background: Burnout has received limited attention in treatment programs, despite high prevalence among health professionals and the threat burnout places upon the mental health and the long-term sustainability of the Australian healthcare system.
M.J. Coleshill, M.J. Black, K. Luck, K. Willis, N. Smallwood, H. Stephens, T. Gillings, L. Fraser, M. Putland, L. Kampel, A.M. Martin, N.F. Praharso, A.D. Joffe, S. Harvey, P.A. Baldwin   +14 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A trial protocol for the effectiveness of digital interventions for preventing depression in adolescents: The Future Proofing Study

Trials, 2020
Background Depression frequently first emerges during adolescence, and one in five young people will experience an episode of depression by the age of 18 years.
Aliza Werner-Seidler, Kit Huckvale, Mark E. Larsen, Alison L. Calear, Kate Maston, Lara Johnston, Michelle Torok, Bridianne O’Dea, Philip J. Batterham, Susanne Schweizer, S. Rachel Skinner, Katharine Steinbeck, Julie Ratcliffe, Ju-Lee Oei, George Patton, Iana Wong, Joanne Beames, Quincy J. J. Wong, Raghu Lingam, Katherine Boydell, Allison M. Salmon, Nicole Cockayne, Andrew Mackinnon, Helen Christensen   +23 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Comment on Hladky-Krage, B.; Hoffman, C.L. Expectations versus Reality of Designer Dog Ownership in the United States. Animals 2022, 12, 3247

Animals
Designer dogs—the result of intentionally crossbreeding purebred dogs, and specifically poodle mixes (a cross between a poodle and a second breed)—have rapidly grown in popularity in recent years [...]
Amanda J. Venturino, Katie M. Weaver, Cornelia Kraus, Jessica P. Hekman   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Mental health and mindfulness amongst Australian fire fighters

BMC Psychology, 2019
Background While extensive research has highlighted the positive mental health outcomes associated with mindfulness, little work has examined how mindfulness may protect the mental health of first responders exposed to trauma.
Isabelle Counson, Dominic Hosemans, Tara J. Lal, Brendan Mott, Samuel B. Harvey, Sadhbh Joyce   +5 more
doaj   +1 more source