Results 31 to 40 of about 221,580 (244)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The impact of universal mental health screening on stigma in primary schools

Child and Adolescent Psychiatry and Mental Health
Background Primary school students struggling with mental health are less likely than high school students to access mental health care, due to barriers such as mental health stigma and low mental health literacy among children and parents.
Annabel Songco, Deanna A. Francis, Emma A. McDermott, Chloe Y. S. Lim, Abigail Allsop, Joseph Croguennec, Gemma Sicouri, Andrew Mackinnon, Jennifer L. Hudson   +8 more
doaj   +1 more source

Can Dogs Limbo? Dogs’ Perception of Affordances for Negotiating an Opening

Animals, 2021
Very little research has focused on canines’ understanding of their own size, and their ability to apply this understanding to their surroundings. The current study tests domestic dogs’ judgment of their body size in relation to a changing environment in
Alexandra Horowitz, Eloise West, Molly Ball, Blakeley Bagwell   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Predictors of depression outcomes among university students following brief smartphone-based interventions

npj Mental Health Research
Smartphone-delivered interventions offer a scalable solution for university students experiencing depression, yet outcomes remain inconsistent. This study examined predictors of depression remission and response in the AI-enhanced Vibe Up adaptive trial ...
Xuanchen Liu, WuYi Zheng, Leonard Hoon, Sunil Gupta, Svetha Venkatesh, Helen Christensen, Jill Newby, Alexis E. Whitton, On behalf of the Vibe Up Trial Consortium   +8 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Optimising the implementation of a universal web-based mental health service for Australian secondary schools: a cluster randomised controlled trial

Child and Adolescent Psychiatry and Mental Health
Background Secondary schools are increasingly delivering a range of mental health interventions with varied success. This trial examined the effectiveness of two implementation strategies, allocation of class time and provision of financial incentives ...
Mirjana Subotic-Kerry, Andrew Mackinnon, Dervla Gallen, Simon Baker, Belinda Louise Parker, Melinda Rose Achilles, Cassandra Chakouch, Nicole Cockayne, Helen Christensen, Bridianne O’Dea   +9 more
doaj   +1 more source

The Essential Network (TEN): consulting stakeholders and experts to better understand implementation of a blended care mental health support services for Australian health professionals

Australian Journal of Psychology
Objective The Essential Network (TEN) is a blended care mental health support service for Australian health professionals. We conducted a series of semi-structured interviews with key stakeholders and researchers to understand health professionals’ needs,
Matthew Coleshill, Kelby Fransisca, Xiaoling Du, Melissa Black, Jill M. Newby, Samuel Harvey, Helen Christensen, Peter Baldwin   +7 more
doaj   +1 more source

The Youth Aware of Mental Health program in Australian Secondary Schools: 3- and 6-month outcomes

International Journal of Mental Health Systems, 2021
Objective The evidence base for suicide prevention programs in Australian schools is limited. The aim of this study was to examine the impact of a universal, mental health promotion and suicide prevention program—Youth Aware of Mental Health (YAM)—on ...
Lauren McGillivray, Fiona Shand, Alison L. Calear, Philip J. Batterham, Demee Rheinberger, Nicola A. Chen, Alexander Burnett, Michelle Torok   +7 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source