Results 31 to 40 of about 236,803 (219)

The Youth Aware of Mental Health program in Australian Secondary Schools: 3- and 6-month outcomes

International Journal of Mental Health Systems, 2021
Objective The evidence base for suicide prevention programs in Australian schools is limited. The aim of this study was to examine the impact of a universal, mental health promotion and suicide prevention program—Youth Aware of Mental Health (YAM)—on ...
Lauren McGillivray, Fiona Shand, Alison L. Calear, Philip J. Batterham, Demee Rheinberger, Nicola A. Chen, Alexander Burnett, Michelle Torok   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The impact of universal mental health screening on stigma in primary schools

Child and Adolescent Psychiatry and Mental Health
Background Primary school students struggling with mental health are less likely than high school students to access mental health care, due to barriers such as mental health stigma and low mental health literacy among children and parents.
Annabel Songco, Deanna A. Francis, Emma A. McDermott, Chloe Y. S. Lim, Abigail Allsop, Joseph Croguennec, Gemma Sicouri, Andrew Mackinnon, Jennifer L. Hudson   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Tackling burnout in Australian doctors by blending a web-based cognitive-behavioural therapy program with telehealth psychological support – protocol for a three-arm randomised-controlled trial

Contemporary Clinical Trials Communications
Background: Burnout has received limited attention in treatment programs, despite high prevalence among health professionals and the threat burnout places upon the mental health and the long-term sustainability of the Australian healthcare system.
M.J. Coleshill, M.J. Black, K. Luck, K. Willis, N. Smallwood, H. Stephens, T. Gillings, L. Fraser, M. Putland, L. Kampel, A.M. Martin, N.F. Praharso, A.D. Joffe, S. Harvey, P.A. Baldwin   +14 more
doaj   +1 more source

Can Dogs Limbo? Dogs’ Perception of Affordances for Negotiating an Opening

Animals, 2021
Very little research has focused on canines’ understanding of their own size, and their ability to apply this understanding to their surroundings. The current study tests domestic dogs’ judgment of their body size in relation to a changing environment in
Alexandra Horowitz, Eloise West, Molly Ball, Blakeley Bagwell   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Optimising the implementation of a universal web-based mental health service for Australian secondary schools: a cluster randomised controlled trial

Child and Adolescent Psychiatry and Mental Health
Background Secondary schools are increasingly delivering a range of mental health interventions with varied success. This trial examined the effectiveness of two implementation strategies, allocation of class time and provision of financial incentives ...
Mirjana Subotic-Kerry, Andrew Mackinnon, Dervla Gallen, Simon Baker, Belinda Louise Parker, Melinda Rose Achilles, Cassandra Chakouch, Nicole Cockayne, Helen Christensen, Bridianne O’Dea   +9 more
doaj   +1 more source

The Essential Network (TEN): consulting stakeholders and experts to better understand implementation of a blended care mental health support services for Australian health professionals

Australian Journal of Psychology
Objective The Essential Network (TEN) is a blended care mental health support service for Australian health professionals. We conducted a series of semi-structured interviews with key stakeholders and researchers to understand health professionals’ needs,
Matthew Coleshill, Kelby Fransisca, Xiaoling Du, Melissa Black, Jill M. Newby, Samuel Harvey, Helen Christensen, Peter Baldwin   +7 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source