Results 21 to 30 of about 221,580 (244)

Preventing mental health symptoms in adolescents using dialectical behaviour therapy skills group: a feasibility study

International Journal of Adolescence and Youth, 2018
Previous prevention programmes have largely focused on the emotion regulation strategy of cognitive reappraisal. The present study is a feasibility trial that evaluates a prevention programme that teaches cognitive reappraisal, acceptance and problem ...
Rowan Burckhardt, Vijaya Manicavasagar, Frances Shaw, Andrea Fogarty, Philip J. Batterham, Katie Dobinson, Ilana Karpin   +6 more
doaj   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Co-designing suicide prevention research with mothers of suicidal adolescents – applying McKercher’s Model of Care

Research Involvement and Engagement
Background Co-design involves a collaborative approach which prioritises doing with, rather than for, the end user. Such practices have numerous benefits for the design and implementation of suicide prevention initiatives.While rigid co-design processes ...
Demee Rheinberger, Katherine Boydell, Susanne Oliver Armstrong, Julia Lessing, Sally Ann Pollard, Inger Jacob, Lauren McGillivray, Emma Elder, Fiona Shand   +8 more
doaj   +1 more source

Implementation and cost effectiveness evaluation of an integrated mental health stepped care service for adults in primary care

International Journal of Integrated Care, 2019
Introduction: After a small successful pilot, and a revision of our implementation model, we trained and worked closely with urban and rural primary health care networks (PHNs) in Australia to implement and evaluate the acceptability, feasability ...
Josephine Anderson1, Judy Proudfoot, Nyree Gale, Helen Christensen, Penny Reeves, Kathleen O'Moore   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Clinician perspectives about delivering a blended care treatment model for adolescent depression: a qualitative study

Child and Adolescent Psychiatry and Mental Health
Background Availability of psychological services for adolescents cannot keep up with demand. Integrating digital interventions with face-to-face care into a blended model, an approach to treatment that incorporates the benefits of both digital and face ...
Alexandra J. South, Adam Theobald, Brittany Corkish, Sophie Li, Melinda Achilles, Mirjana Subotic-Kerry, Bridianne O’Dea, Aliza Werner-Seidler   +7 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Exploring the unique and cumulative effects of individual-level and social determinants on suicidal ideation trajectories during health and environmental crises – a longitudinal study of Australians

BMC Public Health
Background There is a paucity of research that has examined how significant health, social, and environmental crises impact suicidal ideation, particularly where these events co-occur and have potentially synergistic adverse effects.
Quincy J. J. Wong, Sandersan Onie, Lauren McGillivray, Alexander Burnett, Adam Theobald, Fiona Shand, Michelle Torok, Mark E. Larsen   +7 more
doaj   +1 more source

Shorter headed dogs, visually cooperative breeds, younger and playful dogs form eye contact faster with an unfamiliar human

Scientific Reports, 2021
Forming eye contact is important in dog–human communication. In this study we measured what factors affect dogs’ propensity for forming eye contact with an experimenter.
Zsófia Bognár, Dóra Szabó, Alexandra Deés, Enikő Kubinyi   +3 more
doaj   +1 more source