Results 81 to 90 of about 1,447,809 (294)

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

Molecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin, Kjersti Tjensvoll, Karin Hestnes Edland, Satu Oltedal, Herish Garresori, Bjørnar Gilje, Saga Ekedal, Trygve Eftestøl, Jan Terje Kvaløy, Filip Janku, Oddmund Nordgård   +10 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Identifying distinct service use phenotypes across levels of suicidality and self-harm: a UK Biobank study

npj Mental Health Research
Mental health service use among individuals experiencing suicidality and self-harm is highly variable, with many individuals not seeking professional help.
Biya Tang, Fiona Shand, Helen Christensen, Alexis E. Whitton   +3 more
doaj   +1 more source

Emergency department mental health presentations in bushfire-, flood-, storm-, drought-, and COVID-19-affected areas: Analysis of growth models between 2017 and 2021

Australian and New Zealand Journal of Public Health
Objective: Repeated exposure to adverse events increases the possibility of negative emotional consequences and the development of post-traumatic stress disorders. Communities who have faced several extreme weather events and pandemic-related disruptions
Samineh Sanatkar, Samuel B. Harvey, Andrew Mackinnon, Richard Bryant, Grant Sara   +4 more
doaj   +1 more source

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Tapping into truth: an exploratory cross-sectional analysis of psychomotor symptoms and typing behaviour in an adolescent observational cohort

NPP-Digital Psychiatry and Neuroscience
Typing behaviour derived from smartphone keystroke metadata is an emerging digital phenotype that may assist in diagnosing and monitoring depressive symptoms.
Taylor A. Braund, Debopriyo Bal, Helen Christensen, Philip J. Batterham, Bojana Vilus, Kate Maston, Mark E. Larsen, Aliza Werner-Seidler, Kit Huckvale, Alexis E. Whitton, Gabriel Tillman, Bridianne O’Dea   +11 more
doaj   +1 more source

Whatever happened to meaning? Commentary on Millikan: A common structure for concepts of individuals, stuffs, and real kinds [PDF]

, 1998
Even in infancy, concept formation has to do with creating meaning, not with tracking substances. Preverbal infants can identify a substance such as a dog, but their first concept of this substance is not dog but animal.
Mandler, JM
core  

Large scale dog population demography, dog management and bite risk factors analysis: A crucial step towards rabies control in Cambodia

, 2021
Véronique Chevalier, Davun Holl, Sopheak Sorn, Pitou Ly, Vutha Pov, Sowath Ly   +5 more
openalex   +2 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The iBobbly Aboriginal and Torres Strait Islander app project: Study protocol for a randomised controlled trial

Trials, 2019
Background Suicide amongst Australian Aboriginal and Torres Strait Islander communities occurs at twice the rate of the general population and, with significant barriers to treatment, help-seeking prior to a suicide attempt is low.
Fiona Shand, Andrew Mackinnon, Kathleen O’Moore, Rebecca Ridani, Bill Reda, Mel Hoy, Todd Heard, Luke Duffy, Marian Shanahan, Lisa Jackson Pulver, Helen Christensen   +10 more
doaj   +1 more source