Results 71 to 80 of about 228,704 (299)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

What Do We Know about Dog Owners? Exploring Associations between Pre-Purchase Behaviours, Knowledge and Understanding, Ownership Practices, and Dog Welfare

Animals
Despite many dogs living in homes in the UK, there is still more to know about the welfare of those individual animals. Past research has shown that owners’ thoughts and behaviours have a substantial impact on their dog’s welfare.
Izzie Philpotts, Emily J. Blackwell, Justin Dillon, Emma Tipton, Nicola J. Rooney   +4 more
doaj   +1 more source

Exploring the effectiveness of using big books in teaching primary English in Malaysian classrooms [PDF]

, 2008
There are many benefits of using stories for language and literacy development particularly in the areas of vocabulary(Cameron, 2001; Elley, 1989; Penno, Wilkinson & Moore 2002;Hargrave & Senechal, 2000) and reading comprehension.
Pinter, Annamaria, Yaacob, Aizan
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Owner expectations and surprises of dog ownership experiences in the United Kingdom

Frontiers in Veterinary Science
IntroductionAlthough many owners are satisfied by dog ownership, large numbers of dogs are relinquished annually, with an estimated 130,000 dogs cared for each year by rescue organisations in the UK.
Katharine L. Anderson, Katrina E. Holland, Rachel A. Casey, Ben Cooper, Robert M. Christley   +4 more
doaj   +1 more source

Bayesian Optimization Using Domain Knowledge on the ATRIAS Biped

, 2017
Controllers in robotics often consist of expert-designed heuristics, which can be hard to tune in higher dimensions. It is typical to use simulation to learn these parameters, but controllers learned in simulation often don't transfer to hardware.
Antonova, Rika, Atkeson, Christopher G., Geyer, Hartmut, Martin, William, Rai, Akshara, Song, Seungmoon   +5 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Maximising the Potential Benefit of Living with Companion Dogs for Autistic Children and Their Families: A Mixed-Methods Survey of the Impact of a Novel ‘Family Dog Service’

Animals
Background: Assistance dogs can support children with autism by improving emotional regulation and social functioning, but access is limited. The Family Dog Service was developed to help families of autistic children gain similar benefits through ...
Emily Shoesmith, Heidi Stevens, Selina Gibsone, Cari Miles, Hannah Beal, Kelly Jennings, Elena Ratschen   +6 more
doaj   +1 more source

Language acquisition and machine learning [PDF]

, 1986
In this paper, we review recent progress in the field of machine learning and examine its implications for computational models of language acquisition. As a framework for understanding this research, we propose four component tasks involved in learning ...
Carbonell, Jaime G., Langley, Pat
core   +1 more source

Determination of left ventricular mass in dogs with rapid-acquisition cardiac computed tomographic scanning. [PDF]

Circulation, 1985
The development of left ventricular hypertrophy in patients with heart disease often has far-reaching clinical implications with respect to overall morbidity and mortality. Approaches used to assess left ventricular mass include electrocardiography, echocardiography, contrast ventriculography, single photon-emission tomography, and conventional ...
A J, Feiring, J A, Rumberger, S J, Reiter, D J, Skorton, S M, Collins, M J, Lipton, C B, Higgins, S, Ell, M L, Marcus   +8 more
openaire   +2 more sources