Results 61 to 70 of about 316,510 (335)

Dogs Never Gets Prion Diseases. The Entropic Landscape Analysis of Prion Proteins Answers Why. [PDF]

, 2009
The Entropic Landscape Analysis was applied to the prion protein sequences of various mammals in order to detect potential sites of variants that would be responsible for the susceptibility of prion disease infection.
Kentaro Onizuka
core   +1 more source

FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs. [PDF]

, 2017
Chondrodystrophy in dogs is defined by dysplastic, shortened long bones and premature degeneration and calcification of intervertebral discs. Independent genome-wide association analyses for skeletal dysplasia (short limbs) within a single breed ...
Aguilar, Miriam, Bannasch, Danika L, Brown, C Titus, Brown, Emily A, Dickinson, Peter J, Ettinger, Cassandra L, Korff, Courtney, Lind, Jenna, Mansour, Tamer, Pollard, Rachel, Raudsepp, Terje, Sturges, Beverly K, Varon, Samuel, Young, Amy E   +13 more
core   +2 more sources

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Dog size and patterns of disease history across the canine age spectrum: Results from the Dog Aging Project.

PLoS ONE
Age in dogs is associated with the risk of many diseases, and canine size is a major factor in that risk. However, the size patterns are complex. While small size dogs tend to live longer, some diseases are more prevalent among small dogs.
Yunbi Nam, Michelle White, Elinor K Karlsson, Kate E Creevy, Daniel E L Promislow, Robyn L McClelland, Dog Aging Project Consortium   +6 more
doaj   +1 more source

Trends in Allergic Sensitization and Diseases in the Korean General Population Over a 9-Year Period [PDF]

Clinical and Experimental Otorhinolaryngology
Objectives. The prevalence of allergic sensitization and diseases varies over time due to changes in climate, environment, and lifestyle. This study analyzed changes in sensitization to house dust mites (HDM) and dogs, as well as the prevalence of ...
Dong Hee Lee, Ji-Hyeon Shin
doaj   +1 more source

Awareness of Zoonotic Diseases among Dog Owners in an Urban Area of Kancheepuram District, Tamilnadu

National Journal of Community Medicine, 2021
Background: Dogs are the most companion animals of humans and hence they are the direct or indirect source of zoonotic infections. Rabies is an important zoonotic disease in which dogs are the principle reservoir.
Sushmitha Saran, Gopalakrishnan, Ananthaeashwar VM   +2 more
doaj   +1 more source

Necrotizing meningoencephalitis in atypical dog breeds: a case series and literature review. [PDF]

, 2014
BackgroundCanine necrotizing meningoencephalitis (NME) is a fatal, noninfectious inflammatory disease of unknown etiology. NME has been reported only in a small number of dog breeds, which has led to the presumption that it is a breed-restricted disorder.
Cooper, JJ, Levine, JM, Porter, BF, Schatzberg, SJ, Siso, S, Summers, BA, Vernau, KM, Young, BD   +7 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

A prospective cohort study to identify clinical diagnostic and prognostic markers of primary immune thrombocytopenia in dogs

Journal of Veterinary Internal Medicine
Background Primary immune thrombocytopenia (pITP) in dogs presents a diagnostic challenge, and clinical markers of severity are lacking. Objectives Identify clinicopathologic features that differentiate pITP from secondary ITP (sITP) and markers related ...
Marjory B. Brooks, Robert Goggs, Amelia H. Frye, Jessica Armato, Marnin Forman, Julia Hertl, Michael Koch, John P. Loftus, John Lucy, Brandi Mattison, Julia Merriam, Sarah Shropshire, Laura Van Vertloo, Austin Viall, Dana N. LeVine   +14 more
doaj   +1 more source

Unusual case of pleural effusion caused by amlodipine in a dog with systemic hypertension

Veterinary Medicine and Science, 2022
Objective The aim of this report is to document the case of a dog that developed pleural effusion as a potential side‐effect to the administration of a high‐dose of amlodipine.
Hee‐Won Jang, Su‐Min Park, Seo‐young Hwang, Kyuyong Kang, Mincheol Choi, Ju‐Hyun An, Hyung‐Kyu Chae, Ye‐In Oh, Hwa‐Young Youn   +8 more
doaj   +1 more source