Results 51 to 60 of about 308,675 (311)

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source

Competitiveness dogma concerning the sustainability utopia: critical analysis of the developmentalist and economistic ethos [PDF]

, 2016
A través del análisis de discursos y la dialéctica, este artículo tiene como objetivo argumentar de manera crítica el ethos que orienta la apuesta por la competitividad.
Aktouf, Assessment, Bowles, Boyd, Carrizosa, Colvin, Crespo, Daly, Escobar, Escobar, Foucault, Gudynas, Gudynas, Lander, Leff, Leff, Leff, Leff, Martínez-Alier, Mason, Max-Neef, Porter, Porter, Porter, Porter, Pritchard, Riechmann, Ruiz-García, von Bertalanffy, Ángel   +29 more
core   +2 more sources

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

Advanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
wiley   +1 more source

Interpretation of Freedom in the Works of G. K. Chesterton

Kyiv-Mohyla Humanities Journal
In this article, we analyze G.K. Chesterton’s perspective on freedom. In his works, Chesterton emphasizes the importance of defining freedom and accepting its existence.
Aneliya Polshchak
doaj   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Asunción corporal de María a los cielos en los escritores eclesiásticos de la primera mitad del siglo XII

Estudios Eclesiásticos, 1951
El presente estudio abarca los escritores eclesiásticos del periodo comprendido entre san Anselmo y san Bernardo, incluidos algunos discípulos de este último. De manera concreta, se estudian primero los abades benedictinos y demás autores educados en sus
Ignacio Riudor
doaj  

Multi‐Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs

Advanced Science, EarlyView.
Integrated multi‐omics across pig breeds and tissues reveals key principles of post‐transcriptional translational regulation and their contribution to trait formation. A gene network framework integrating transcriptomic and translatomic data is developed and applied to elucidate the genetic basis of meat production, offering new insights into mammalian
Chao Wang, Yuanyuan Zhang, Choulin Chen, Xiaoxian Xu, Shenghua Qin, Junyan Qi, Yongzhou Bao, Huiming Li, Ruipu Chen, Weigang Zheng, Zhilong Chen, Lingzhao Fang, Yunxiang Zhao, Yuwen Liu   +13 more
wiley   +1 more source

Support‐Induced Interfacial Effects Steer Methanol Selectivity in CO2 Electroreduction by Immobilized Cobalt Phthalocyanine

Angewandte Chemie, EarlyView.
Immobilizing CoPc on a carbon support switches its CO2 reduction selectivity from CO to CH3OH. Multiscale simulations reveal that the support actively modulates the catalytic environment by inducing desolvation of bottom layer of CoPc, which lowers the protonation barrier while leaving CO desorption nearly unaffected.
Ke Ye, Min Hu, Guozhen Zhang, Mårten S. G. Ahlquist   +3 more
wiley   +2 more sources

El Dogma danés [PDF]

, 2010
La posibilidad de un artículo que responda al título del presente (y, sobre todo, que satisfaga las elevadas exigencias que éste im- pone) se me antoja inasequible, por varios motivos: en primer término, porque excluye implícitamente de entrada la ...
Rubio Alcover, Agustín
core   +1 more source

Structural problems without structural solutions? Youth leaders' perceptions of their community

American Journal of Community Psychology, EarlyView.
Abstract As young people explore and reflect on the conditions of their neighborhoods and communities, they can forge a critical consciousness—merging their perspectives and analysis to direct both individual and collective actions. Photovoice is a methodological tool that allows participants to document their perspectives and analysis and discuss with
Linnea L. Hjelm, Aishia A. Brown, Benjamin W. Fisher, Alice Story, Nubia Bennett   +4 more
wiley   +1 more source