Results 31 to 40 of about 1,190,922 (296)

Does canine inflammatory bowel disease influence gut microbial profile and host metabolism? [PDF]

, 2016
Background: Inflammatory bowel disease (IBD) refers to a diverse group of chronic gastrointestinal diseases, and gut microbial dysbiosis has been proposed as a modulating factor in its pathogenesis.
Bosch, Guido, Eeckhaut, Venessa, Hesta, Myriam, Janssens, Geert, Junius, Greet, Liu, Daisy, Niu, Yufeng, Ribeiro Alves Lourenço, Marta, Van de Maele, Isabel, Van de Wiele, Tom, Van Immerseel, Filip, Verbrugghe, Adronie, Wuyts, Brigitte, Xu, Jia   +13 more
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in england [PDF]

, 2015
Background To date, epidemiological studies on degenerative mitral valve disease (DMVD) in dogs have largely reported referral caseloads or been limited to predisposed breeds.
Bavegems, Borgarelli, Borgarelli, Borgarelli, Buchanan, Bussadori, Chetboul, Darke, Das, Detweiler, Dohoo, Egenvall, Fabrizio, Haggstrom, Heinze, Jones, Kearsley-Fleet, Lundin, Mattin, O'Neill, Olsen, Olsen, Parker, Pedersen, Pfeiffer, Serfass, Slater, StataCorp, Thrusfield, Whitney   +29 more
core   +3 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Canine-centered interface design: supporting the work of diabetes alert dogs [PDF]

, 2014
Many people with Diabetes live with the continuous threat of hypoglycaemic attacks and the danger of going into coma. Diabetic Alert Dogs are trained to detect the onset of an attack before the human handler they are paired with deteriorates, giving them
Guest, Claire, Harris, Rob, Mancini, Clara, Robinson, Charlotte, van der Linden, Janet   +4 more
core   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Geographic Availability of Assistance Dogs: Dogs Placed in 2013-2014 by ADI- or IGDF-Accredited or Candidate Facilities in the United States and Canada, and Non-accredited U.S. Facilities. [PDF]

, 2019
Assistance dogs' roles have diversified to support people with various disabilities, especially in the U.S. Data presented here are from the U.S. and Canada non-profit facilities (including both accredited and candidate members that fulfilled partial ...
Hart, Lynette A, Thigpen, Abigail P, Walther, Sandra, Willits, Neil H, Yamamoto, Mariko   +4 more
core  

Social dog — emotional dog?

Animal Sentience, 2017
Based on their high sociability and their capabilities in social cognition, we should consider that dogs experience rich emotions in the social domain. I discuss the importance of dog-human attachment and some of the controversial evidence for so-called secondary emotions, which leaves many questions to answer.
openaire   +3 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Painted Ferocity: The Social Behaviors of African Wild Dogs, Threats to Survival, and Resulting Conservation Initiatives [PDF]

, 2018
African Wild Dogs (Lycaon pictus) are an endangered species of canid from Sub-Saharan Africa. They are very social communal hunters, and are capable of chasing down prey for long stretches of time. Wild dogs benefit a savannah ecosystem by regulating the
Valdes, Alexis
core   +1 more source