Results 81 to 90 of about 542,277 (296)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Affixation patterns in native language and sequence processing by statistical learning mechanisms

Evolutionary Human Sciences
The suffixing bias (the tendency to exploit suffixes more often than prefixes to express grammatical meanings) in languages was identified a century ago, yet we still lack a clear account for why it emerged, namely, whether the bias emerged because ...
Mikhail Ordin
doaj   +1 more source

GCL – An Easy Way for Creating Graphical User Interfaces [PDF]

Journal of Systemics, Cybernetics and Informatics, 2011
Graphical User Interfaces (GUI) can be created using several approaches. Beside using visual editors or a manually written source code, it is possible to employ a declarative method.
Mariusz Trzaska
doaj  

From Grammar Inference to Semantic Inference—An Evolutionary Approach

Mathematics, 2020
This paper describes a research work on Semantic Inference, which can be regarded as an extension of Grammar Inference. The main task of Grammar Inference is to induce a grammatical structure from a set of positive samples (programs), which can sometimes
Željko Kovačević, Marjan Mernik, Miha Ravber, Matej Črepinšek   +3 more
doaj   +1 more source

Modeling and simulation of data communication networks using SARA [PDF]

, 1985
The selection of an appropriate simulation language can have a profound impact on the success of a simulation study. The available options range from domain-specific simulation languages to general-purpose programming languages. These languages are often
Razouk, Rami R.
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Formalization and visualization of domain-specific software architectures [PDF]

This paper describes a domain-specific software design system based on the concepts of software architectures engineering and domain-specific models and languages.
Bailor, Paul D., Luginbuhl, David R., Robinson, John S.   +2 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source