Results 61 to 70 of about 76,835 (265)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Using English-Based NLP Tools for Domain-Specific Text in Foreign Languages

IEEE Access
Social scientists often machine-translate foreign-language texts into English and apply English-based natural language processing tools without systematically evaluating translation quality or annotation efficiency.
Naif Alatrush, Luay Abdeljaber, Javier Osorio, Dagmar Heintze, Brikena Liko, Patrick T. Brandt, Latifur Khan, Vito J. D'Orazio, Sultan Alsarra   +8 more
doaj   +1 more source

From Grammar Inference to Semantic Inference—An Evolutionary Approach

Mathematics, 2020
This paper describes a research work on Semantic Inference, which can be regarded as an extension of Grammar Inference. The main task of Grammar Inference is to induce a grammatical structure from a set of positive samples (programs), which can sometimes
Željko Kovačević, Marjan Mernik, Miha Ravber, Matej Črepinšek   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Affixation patterns in native language and sequence processing by statistical learning mechanisms

Evolutionary Human Sciences
The suffixing bias (the tendency to exploit suffixes more often than prefixes to express grammatical meanings) in languages was identified a century ago, yet we still lack a clear account for why it emerged, namely, whether the bias emerged because ...
Mikhail Ordin
doaj   +1 more source

GCL – An Easy Way for Creating Graphical User Interfaces [PDF]

Journal of Systemics, Cybernetics and Informatics, 2011
Graphical User Interfaces (GUI) can be created using several approaches. Beside using visual editors or a manually written source code, it is possible to employ a declarative method.
Mariusz Trzaska
doaj  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Domain Specific Languages

International Journal of Computer Applications, 2010
To match the needs of the fast paced generation, the speed of computing has also increased enormously. But, there is a limit to which the processor speed can be amplified. Hence in order to increase productivity, there is a need to change focus from processing time to programming time.
Aruna Raja, Devika Lakshmanan
openaire   +1 more source