Results 51 to 60 of about 71,900 (266)
Will we think in programming languages?
Acta Informatica Pragensia, 2012 Modern science commonly uses computer modelling. Thousands of scientific model are daily transformed to computers programs and tested. The transformation must overcome the gap between abstract human formal notation and low level semantics of contemporary
Jiří Fišer
doaj
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Cognitive Behaviors Modeling Using UML Profile: Design and Experience
IEEE Access, 2017 To achieve model reuse in combat effectiveness simulation systems development, cognitive decision behaviors are usually implemented using a scripting language, which is separate from the programming language used to implement simulation models. Therefore,
Zhi Zhu +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
A domain-specific language for microservices
Proceedings of the 9th ACM SIGPLAN International Symposium on Scala, 2018 A common architectural pattern for complex online systems is a collection of “microservices” communicating via RPC interfaces. A service architecture provides autonomy for teams to develop, deploy, and operate system modules without centralized coordination.
openaire +1 more source
Visual Dataflow Language for Educational Robots Programming
Труды Института системного программирования РАН, 2018 Visual domain-specific languages usually have low entry barrier. Sometimes even children can program on such languages by working with visual representations.
G. A. Zimin, D. A. Mordvinov
doaj +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
TESMA: Requirements and Design of a Tool for Educational Programs †
Information, 2017 Defining and managing teaching programs at universities or other institutions is a complex task for which there is not much support in terms of methods and tools.
Nicolas Guelfi +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source