Results 31 to 40 of about 83,445 (219)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Will we think in programming languages?

Acta Informatica Pragensia, 2012
Modern science commonly uses computer modelling. Thousands of scientific model are daily transformed to computers programs and tested. The transformation must overcome the gap between abstract human formal notation and low level semantics of contemporary
Jiří Fišer
doaj  

Wodel-Test: A model-based framework for engineering language-specific mutation testing tools

SoftwareX
Mutation testing (MuT) is a well-known technique for assessing the quality of software test suites. It relies on the artificial injection of errors into the source code, which results in a collection of variations called mutants.
Pablo Gómez-Abajo, Esther Guerra, Juan de Lara   +2 more
doaj   +1 more source

Code generation approaches for parallel geometric multigrid solvers

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2020
Software development for applications in computational science and engineering has become complex in recent years. This is mainly due to the increasing parallelism and heterogeneity in modern computer architectures and to the more realistic physical and ...
Köstler Harald, Heisig Marco, Kohl Nils, Kuckuk Sebastian, Bauer Martin, Rüde Ulrich   +5 more
doaj   +1 more source

Digital Activities in Teaching/Learning a Foreign Language for Specific Purposes, Technical/Scientific Domain [PDF]

Journal of Humanistic and Social Studies, 2021
The present pandemic has determined the teachers to adopt new methods of on-line teaching and learning and the specific activities within the classes of foreign languages for special purposes, technical and scientific domain are part of these new ...
Cristina Ana Măluţan, Monica Negoescu
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cognitive Behaviors Modeling Using UML Profile: Design and Experience

IEEE Access, 2017
To achieve model reuse in combat effectiveness simulation systems development, cognitive decision behaviors are usually implemented using a scripting language, which is separate from the programming language used to implement simulation models. Therefore,
Zhi Zhu, Yonglin Lei, Yifan Zhu, Hessam Sarjoughian   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source