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A Survey on Modeling Languages for Applications Hosted on Cloud-Edge Computing Environments
Applied SciencesIn the field of edge-cloud computing environments, there is a continuous quest for new and simplified methods to automate the deployment and runtime adaptation to application lifecycle changes.
Ioannis Korontanis +2 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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Support for Visual Languages Evolution in DSM-platform QReal
Моделирование и анализ информационных систем, 2014 Like other software artefacts, DSMLs evolve in time. When a DSML changes, instance models might no longer conform to the new DSML metamodel and hence cannot be manipulated with a modelling tool.
T. Y. Agapova, T. A. Bryksin
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
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Quality-Driven Detection and Resolution of Metamodel Smells
IEEE Access, 2019 In model-driven engineering, analogously to any software development practice, metamodel design must be accurate and performed by considering relevant quality factors, including maintainability, reusability, and understandability.
Lorenzo Bettini +3 more
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
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Domain-Specific Languages for Algorithmic Graph Processing: A Systematic Literature Review
AlgorithmsGraph analytics has grown increasingly popular as a model for data analytics across a variety of domains. This has prompted an emergence of solutions for large-scale graph analytics, many of which integrate user-facing domain-specific languages (DSLs) to
Houda Boukham +2 more
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Frontiers in Computer Science, 2023 IntroductionBlended modeling aims at boosting the development of complex multi-domain systems by enabling seamless multi-notation modeling. The synchronization mechanisms between notations are embodied in model transformations.
Malvina Latifaj +2 more
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FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
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Encontros Bibli, 2010 While metadata has been a strong focus within information professionals’ publications, projects, and initiatives during the last two decades, a significant number of domain-specific markup languages have also been developing on a parallel path at the ...
Marcia Lei Zeng
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