Results 121 to 130 of about 549,366 (277)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Unsupervised Domain Adaptation for Constraining Star Formation Histories

Astronomy
In astronomy, understanding the evolutionary trajectories of galaxies necessitates a robust analysis of their star formation histories (SFHs), a task complicated by our inability to observe these vast celestial entities throughout their billion-year ...
Sankalp Gilda, Antoine de Mathelin, Sabine Bellstedt, Guillaume Richard   +3 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Predicting unseen lithium-ion battery degradation modes through domain generalization

Energy Reports
The rapid development of modern society and the increasing energy demand have made secondary batteries one of the most promising energy storage systems. Among these, lithium-ion batteries are currently the most widely used.
Gamsung Shin, Yonggon Jung, Jun-Geol Baek   +2 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Consistent Augmentation Learning for Generalizing CLIP to Unseen Domains

IEEE Access
Domain generalization (DG) is a challenging transfer learning task focused on learning invariant knowledge from limited source domains, thereby enhancing generalization to the out-of-distribution data in unseen domains.
Qinan Xuan, Tianyuan Yu, Liang Bai, Yirun Ruan   +3 more
doaj   +1 more source

Generalizing domain theory [PDF]

, 1998
Domain theory began in an attempt to provide mathematical models for high-level programming languages, an area where it has proved to be particularly useful. It is perhaps the most widely-used method for devising semantic models for such languages. This paper is a survey of some generalizations of domain theory that have arisen in efforts to solve ...
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

NAS-DG: Ultra-Fast NAS via Uncertainty Modeling for Domain Generalization

IEEE Access
Designing neural network architectures manually is time-consuming and labor-intensive when applying deep learning to various tasks and datasets. Neural architecture search (NAS) has been proposed to automate this process, but existing methods mainly aim ...
Keigo Wakayama, Takafumi Kanamori
doaj   +1 more source