Results 111 to 120 of about 424,597 (303)

The cybersquatting as a form of unfair competition: economic and legal features and countermeasures

open access: yesТеорія і практика інтелектуальної власності
The author comprehensively researched the economic and legal features of cybersquatting as a computer crime from the position of its economic and legal meaning; economic factors of attractiveness (passivity of business, simplicity of doing business ...
Oleksandr Butnik-Siverskyi
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Domain Name System [PDF]

open access: yes, 2007
Práce se zabývá službou Domain Name System. Jsou zde uvedeny základní pojmy i normy týkající se DNS. Obsahuje obecný postup implementace DNS ve Windows 2000 Server a v Linuxu. V závěrečné kapitole je uveden praktický příklad implementace DNS ve virtuální
Dostál, Luboš
core  

Sketch-based caching method for significant DNS queries

open access: yes网络与信息安全学报
With the rapid advancement of networking technology, DNS (domain name system), acting as the first step for most network behaviors, plays a vital role in assuring service quality through its capability and security.
HAO Yihang   +6 more
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Domain name law : from registration to dispute resolution [PDF]

open access: yes, 2015
Powerpoint preseentation Outline: Domain name law -- Domain name disputes and other types of online disputes -- Domain name dispute resolution policies, UDRP, auDRP -- Domain name law practice and ...
Roy, Alpana (R18105)
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

"Sucks Cases" in WIPO Domain Name Decisions [PDF]

open access: yes, 2008
Does the use of a domain name for criticism constitute the use of the domainname in Bad Faith?   Is there any right to register a domain name confusingly similar with the name ofa well known company to tell other people that it is vivisecting animals? Or
Koščík, Michal
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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