Results 121 to 130 of about 424,597 (303)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Deconstructing domain name law [PDF]
, 2014 Covers approaches to legal problem-solving in internet law as well as discussing how aspects of infringement in cyberspace can be addressed by using existing legal principles (eg, trade mark law, ACL and passing off, copyright law, etc).
Roy, Alpana (R18105)
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Trust on the Internet : How the French ccTLD.FR Went From a Remarkable to a Speculative System [PDF]
, 2017 The Domain Name System (DNS), was invented in 1983 because it was too hard for the human brain to memorize IP addresses. The DNS works as a phone directory, setting a link between letters, the domain name, and an IP address.
GENTY, Clément +2 more
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Setonix: Blockchain-Based Hierarchy Domain Name System for Web3
Applied SciencesDNS is an essential component for internet access, but the traditional centralized structure is not suitable for the rapidly growing Web3 ecosystem. Currently, Web3 services rely on Web2-based access paths, revealing limitations such as the Single Point ...
Juseong Jeon, Sejin Park
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Protecting of internet domain name rights [PDF]
, 2011 Alan adları internetin kullanılmaya başlamasından sonra ortaya çıkmıştır. İnternet Tahsisli Sayılar ve Adlar Kurumu (Internet Corporation For Assigned Names and Numbers- ICANN) alan adlarının küresel yönetiminde yetkilidir.
Oğuz, Sefer
core
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Domain disputes and arbitration under the UDRP: Legal issues and new (old) challenges
Цифровое правоIn this article, we delve into a comprehensive study of the legal nature of proceedings regulated by the Uniform Domain Name Dispute Resolution Policy (UDRP).
M. A. Rozhkova, E. V. Alymova
doaj +1 more source