Results 51 to 60 of about 81,008 (307)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
A Survey on Modeling Languages for Applications Hosted on Cloud-Edge Computing Environments
Applied SciencesIn the field of edge-cloud computing environments, there is a continuous quest for new and simplified methods to automate the deployment and runtime adaptation to application lifecycle changes.
Ioannis Korontanis +2 more
doaj +1 more source
Support for Visual Languages Evolution in DSM-platform QReal
Моделирование и анализ информационных систем, 2014 Like other software artefacts, DSMLs evolve in time. When a DSML changes, instance models might no longer conform to the new DSML metamodel and hence cannot be manipulated with a modelling tool.
T. Y. Agapova, T. A. Bryksin
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Domain-Specific Languages for Algorithmic Graph Processing: A Systematic Literature Review
AlgorithmsGraph analytics has grown increasingly popular as a model for data analytics across a variety of domains. This has prompted an emergence of solutions for large-scale graph analytics, many of which integrate user-facing domain-specific languages (DSLs) to
Houda Boukham +2 more
doaj +1 more source
Quality-Driven Detection and Resolution of Metamodel Smells
IEEE Access, 2019 In model-driven engineering, analogously to any software development practice, metamodel design must be accurate and performed by considering relevant quality factors, including maintainability, reusability, and understandability.
Lorenzo Bettini +3 more
doaj +1 more source
Conceptual Model of the Globalization for Domain-Specific Languages
, 2022 S.7 ...
Rumpe, B. +3 more
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Frontiers in Computer Science, 2023 IntroductionBlended modeling aims at boosting the development of complex multi-domain systems by enabling seamless multi-notation modeling. The synchronization mechanisms between notations are embodied in model transformations.
Malvina Latifaj +2 more
doaj +1 more source