Results 61 to 70 of about 81,008 (307)

JAMOOS - A Domain-Specific Language for Language Processing

Journal of Computing and Information Technology, 2001
Summary: JAMOOS is a cohesive suite for quick definition of attribute grammars and generation of compilers, interpreters and other language processing tools. As a programming language, JAMOOS brings a new tree computing metaphor which unifies the notions of object creation, procedure call and reduction of rules in an attribute context-free grammar ...
Gil, Joseph, Tsoglin, Yuri
openaire   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Domain-Specific Languages in Practice [PDF]

, 2021
This book covers several topics related to domain-specific language (DSL) engineering in general and how they can be handled by means of the JetBrains Meta Programming System (MPS), an open source language workbench developed by JetBrains over the last 15 years.
Bucchiarone A., Cicchetti A., Ciccozzi F., Pierantonio A.   +3 more
openaire   +3 more sources

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Wodel-Test: A model-based framework for engineering language-specific mutation testing tools

SoftwareX
Mutation testing (MuT) is a well-known technique for assessing the quality of software test suites. It relies on the artificial injection of errors into the source code, which results in a collection of variations called mutants.
Pablo Gómez-Abajo, Esther Guerra, Juan de Lara   +2 more
doaj   +1 more source

Building specifications as a domain-specific aspect language [PDF]

Proceedings of the seventh workshop on Domain-Specific Aspect Languages, 2012
In the construction industry an increasing number of buildings are designed using semantically rich three-dimensional models. In parallel, additional information is specified in a natural-language document called a building specification. As not all details are present in the model these specifications have to be interpreted whenever costs are ...
Max E. Kramer, Jacques Klein, Jim R. H. Steel   +2 more
openaire   +3 more sources

Evolving a DSL implementation

, 2008
Domain Specific Languages (DSLs) are small languages designed for use in a specific domain. DSLs typically evolve quite radically throughout their lifetime, but current DSL implementation approaches are often clumsy in the face of such evolution. In this
Laurence Tratt, Tratt, Laurence
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Will we think in programming languages?

Acta Informatica Pragensia, 2012
Modern science commonly uses computer modelling. Thousands of scientific model are daily transformed to computers programs and tested. The transformation must overcome the gap between abstract human formal notation and low level semantics of contemporary
Jiří Fišer
doaj