Results 191 to 200 of about 1,858,236 (277)

Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms. [PDF]

Cell Rep, 2019
Ghosh E, Dwivedi H, Baidya M, Srivastava A, Kumari P, Stepniewski T, Kim HR, Lee MH, van Gastel J, Chaturvedi M, Roy D, Pandey S, Maharana J, Guixà-González R, Luttrell LM, Chung KY, Dutta S, Selent J, Shukla AK.   +18 more
europepmc   +1 more source

Rational Design of Heterodimeric Protein using Domain Swapping for Myoglobin

Protein design is a useful method to create novel artificial proteins. A rational approach to design a heterodimeric protein using domain swapping for horse myoglobin (Mb) was developed. As confirmed by X-ray crystallographic analysis, a heterodimeric Mb
Higuchi, Yoshiki, Hirota, Shun, Shomura, Yasuhito, Nagao, Satoshi, Lin, Ying-Wu, Zhang, Mohan   +5 more
core  

The Influence of Drosophila Spire and Myosin V During Mid‐Oogenesis Is Independent of Their Direct Interaction

Cytoskeleton, EarlyView.
ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong, Hannah M. Bailey, Emma Carley, Michelle Panzica, Merin Rixen, Neil Billington, Rong Liu, Margot E. Quinlan   +7 more
wiley   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source

Differential sensitivity to SHH signaling and neural crest‐mediated Gas1 expression regulate jaw size during development and evolution

Developmental Dynamics, EarlyView.
Abstract Background Developmental control of jaw size is crucial to prevent birth defects and facilitate evolutionary adaptation. We have shown that jaw size is established by neural crest mesenchyme (NCM), which are progenitor cells that migrate into the mandibular primordia and produce the jaws.
Zuzana Vavrušová, Daniel B. Chu, An Nguyen, Yeniko Ta, Jennifer L. Fish, Richard A. Schneider   +5 more
wiley   +1 more source

The unique trimeric assembly of the virulence factor HtrA from Helicobacter pylori occurs via N-terminal domain swapping. [PDF]

J Biol Chem, 2019
Zhang Z, Huang Q, Tao X, Song G, Zheng P, Li H, Sun H, Xia W.   +7 more
europepmc   +1 more source

Asymmetric species turnover underpins the latitudinal diversity gradient in the Western Ghats biodiversity hotspot of India

Ecography, EarlyView.
Latitudinal diversity gradients (LDGs), namely an increase in species richness from higher to lower latitudes, are one of ecology's best documented patterns, yet how the fundamental components of compositional mismatches (i.e. species gains and losses along a gradient) explain these patterns remains poorly understood.
Rohitashva Shukla, Vidyadhar Atkore, Anuradha Bhat, Neelesh Dahanukar, Jeyaraj Antony Johnson, Rajeev Raghavan, Maria Dornelas, Kartik Shanker, Anne E. Magurran   +8 more
wiley   +1 more source

Low‐Dimensional Materials and Van Der Waals Heterostructures for Energy Application: A Comprehensive Review

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Low‐dimensional materials (0D, 1D, and 2D) exhibit unique electronic and physicochemical properties, enabling advanced nanoelectronic and optoelectronic devices. Mixed‐dimensional heterostructures combine these materials to enhance functionality.
Qaisar Alam, Sajjad Ali, Pir Muhammad Ismail, ABM Sharif Hossain   +3 more
wiley   +1 more source

Domain swapping and SMYD1 interactions with the PWWP domain of human hepatoma-derived growth factor. [PDF]

Sci Rep, 2018
Chen LY, Huang YC, Huang ST, Hsieh YC, Guan HH, Chen NC, Chuankhayan P, Yoshimura M, Tai MH, Chen CJ.   +9 more
europepmc   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source