Results 221 to 230 of about 22,091 (247)
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Nucleation process in the folding of a domain-swapped dimer
Physical Review E, 2010Nucleation processes are important for the understanding in protein dynamics. To evaluate the effect of nucleation mechanism in dimerization process, a domain-swapped dimer (Esp8) is simulated with the symmetrized Gō model and the classical Gō model. The pathways of the dimerization are analyzed with computational phi -analysis method.
Zhiqiang, Yan +4 more
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Coupling of Domain Swapping to Kinetic Stability in a Thioredoxin Mutant [PDF]
Journal of Molecular Biology, 2009 The thioredoxin (Trx) fold is a small monomeric domain that is ubiquitous in redox-active enzymes. Trxs are characterized by a typical WCGPC active-site sequence motif. A single active-site mutation of the tryptophan to an alanine in Staphylococcus aureus Trx converts the oxidized protein into a biologically inactive domain-swapped dimer.
Garcia-Pino, Abel +5 more
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Domain Swaps to Phenotype Shifts
Science Signaling, 2010Systematic swapping of modular protein domains verifies a mechanism for generation of phenotypic diversity in yeast.
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Three-dimensional domain duplication, swapping and stealing
Current Opinion in Structural Biology, 1997Examination of multidomain and/or multimeric protein structures can reveal evolutionary paths to a more complex 3D organization. Over the past few years, proteins have been shown to evolve while preserving mutual domain organization and interfaces. The recent advances in understanding domain reorganization and mobility highlight the versatility and ...
J, Heringa, W R, Taylor
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Domain-swapped structure of a mutant of cyanovirin-N
Biochemical and Biophysical Research Communications, 2002Cyanovirin-N (CV-N) is a potent 11 kDa HIV-inactivating protein that binds with high affinity to the HIV surface envelope protein gp120. A double mutant P51S/S52P of CV-N was engineered by swapping two critical hinge-region residues Pro51 and Ser52. This mutant has biochemical and biophysical characteristics equivalent to the wild-type CV-N and its ...
Istvan, Botos +4 more
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Structure of infectious prions: stabilization by domain swapping
The FASEB Journal, 2005ABSTRACT A candidate structure for the minimal prion infectious unit is a recently discovered protein oligomer modeled as a β‐helical prion trimer (BPT); BPTs can stack to form cross‐β fibrils and may provide insight into protein aggregates of other amyloid diseases.
Sichun, Yang +3 more
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Comparison of backbone dynamics of monomeric and domain‐swapped stefin A
Proteins: Structure, Function, and Bioinformatics, 2004AbstractThree‐dimensional domain swapping has been observed in increasing number of proteins and has been implicated in the initial stages of protein aggregation, including that of the cystatins. Stefin A folds as a monomer under native conditions, while under some denaturing conditions domain‐swapped dimer is formed.
Japelj, Boštjan +2 more
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TCX: Texture and Channel Swappings for Domain Generalization
SSRN Electronic Journal, 2022Jaehyun Choi +3 more
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Adaptive Feature Swapping for Unsupervised Domain Adaptation
Proceedings of the 31st ACM International Conference on Multimedia, 2023Junbao Zhuo +4 more
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