Results 61 to 70 of about 3,279 (191)

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Safety, Tolerability, Pharmacokinetics and Exploratory Pharmacodynamics of Melanin‐Concentrating Hormone Receptor‐1 Antagonist RGH‐706 in Healthy and Overweight or Obese Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim This Phase 1 program evaluated the safety, tolerability, pharmacokinetics and exploratory pharmacodynamics of the novel melanin‐concentrating hormone receptor‐1 antagonist RGH‐706. Methods Study A was a first‐in‐man, randomized trial comprising a double‐blind, placebo‐controlled single‐ascending‐dose part (0.1–162.5 mg) and a two‐way ...
Thomas Brevig, Borbála Szepes, Zsófia Borbála Dombi, Gabriella Magyar, Zoltán Juhász, Margit Kapás, Éva Cseh, Zsuzsa Hegedűs, Tibor Farkas, Zsuzsanna Kiss, Balázs Szatmári   +10 more
wiley   +1 more source

Bipolar Neutrosophic Dombi-Based Heronian Mean Operators and Their Application in Multi-criteria Decision-Making Problems

International Journal of Computational Intelligence Systems
Dombi operations based on the Dombi t-norm (TN) and t-conorm (TCN) have the advantage in terms of operational parameter flexibility in dealing with varying degrees of uncertainty and aggregation requirements.
Siti Nurhidayah Yaacob, Hazwani Hashim, Noor Azzah Awang, Nor Hashimah Sulaiman, Ashraf Al-Quran, Lazim Abdullah   +5 more
doaj   +1 more source

Multi Label Feature Selection Through Dual Hesitant q-Rung Orthopair Fuzzy Dombi Aggregation Operators

IEEE Access, 2022
In this article, the feature selection (FS) process is taken as a multi criteria decision making (MCDM) problem. Also, to consider the impreciseness arising in the real time data, the values of the decision matrix procured after the ridge regression is ...
S. Kavitha, K. Janani, J. Satheesh Kumar, Mahmoud M. Elkhouly, T. Amudha   +4 more
doaj   +1 more source

Second Language Interactional Competence in Roleplay: Comparing Generative Artificial Intelligence and Human Interlocutors

Language Learning, EarlyView.
Abstract This study explores the potential of generative artificial intelligence (GenAI) as an alternative to human interlocutors for assessing interactional competence (IC) in a second language (L2). Thirty L2 English speakers completed a 6‐item roleplay task designed to elicit refusals of requests, invitations, and offers, interacting with both a ...
Yunwen Su, Xi Chen
wiley   +1 more source

Selumetinib as a Target Therapy in Progressive Paediatric Low‐Grade Gliomas—Case Series (pLGG)

Journal of Paediatrics and Child Health, Volume 62, Issue 8, Page 1499-1508, August 2026.
ABSTRACT Background Optic pathway gliomas (OPGs) occur in 15%–20% of children with neurofibromatosis type 1 (NF1). While smaller gliomas may be only monitored, the current standard of care for symptomatic ones relies on chemotherapy, most commonly carboplatin and vincristine.
Laura Trapani, Giulia Gortani, Andrea Magnolato, Flora Maria Murru, Elisabetta Cattaruzzi, Laura Diplotti, Paola Michieletto, Silvia Giganti, Davide Zanon, Alessandra Maestro, Valentina Kiren, Egidio Barbi, Irene Bruno   +12 more
wiley   +1 more source

A Multi-attribute Decision Making Method for the Evaluation of Software Enterprise Based on T-Spherical Fuzzy Dombi Aggregation Information

, 2022
Dealing with uncertain and incomplete information is a challenging task and several fuzzy frameworks have been established.. T-spherical fuzzy set (TSFS) is one of the freshly established models that associate human opinion with a membership grade (MG ...
Garg, Harish, Gul, Zunaira, Ullah, Kifayat, Mahmood, Tahir   +3 more
core   +1 more source

Evaluation of autonomous vehicle applications in smart airports using Dombi Bonferroni mean operator based CIVL-BWM-TODIM decision making methodology [PDF]

Title on author's file: Evaluation of Autonomous Vehicle Applications in Smart Airports using Dombi Bonferroni Operator based CIVL-BWM-TODIM Decision Making Methodology202407 bcchSelf-fundedPublished24 monthsGreen ...
Wen, X, Chung, SH, Liu, L
core   +1 more source

Designing a Green Chiral High‐Performance Liquid Chromatography Method: Proof‐of‐Concept with Crizotinib

Chemistry–Methods, Volume 6, Issue 2, February 2026.
A sustainable HPLC approach was developed for the enantioseparation of crizotinib using polysaccharide‐based chiral stationary phases under polar‐organic and reversed‐phase conditions. Experimental‐design optimization and greenness/whiteness assessment (AGREE, Eco‐Scale, Complex MoGAPI, AMGS, and RGB‐fast) identified an ethanol–water system as the most
Ali Mhammad, Gergely Dombi, Máté Dobó, Eliza Tóth, Gergely Molnár, Arash Mirzahosseini, Zoltán‐István Szabó, Gergő Tóth   +7 more
wiley   +1 more source

Exploring Optimal Locations for Large‐Scale Grid‐Connected Solar Photovoltaic Installation Using Interval‐Valued Spherical Fuzzy MCDM With Multi‐Panel Techno‐Economic Assessment

IET Renewable Power Generation, Volume 20, Issue 1, January/December 2026.
Introduces an Interval‐Valued Spherical Fuzzy SIWEC‐SPOTIS approach for PV site selection. The proposed model is validated through rank reversal, sensitivity, and comparative study. Solar irradiation received the highest weight, while mean wind speed received the lowest. Tangail district was ranked the most suitable, while Shariatpur ranked the lowest.
Tausif Ali, Ahmet Aytekin, Mihail Demidionov, Md. Tareq Aziz   +3 more
wiley   +1 more source