Results 81 to 90 of about 3,495,562 (311)

TTNPB Promotes Human Pluripotent Stem Cell‐to‐Neural Stem Cell Transition via Modulation of Chromatin Accessibility and the S‐(5′‐adenosyl)‐L‐homocysteine/Choline Metabolic Network

open access: yesAdvanced Science, EarlyView.
A retinoic acid receptor agonist, TTNPB, drives the efficient generation of advanced neural stem cells (ANSCs) from human pluripotent stem cells. TTNPB‐centered chromatin remodeling and metabolic reprogramming, promote neuroectoderm commitment. The resulting cells show robust neural potential and functional efficacy in a rat depression model.
Ruilin Du   +17 more
wiley   +1 more source

Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits

open access: yesAdvanced Science, EarlyView.
A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao   +8 more
wiley   +1 more source

Performing the Networks of Domestic and Public Persona

open access: yesPersona Studies, 2016
In this preamble to the newest collection of contributions to Persona Studies, we draw on the growing terminology from its initial offerings to consider the co-infiltration of the public and the domestic in the presentation of the online self. We provide
Christopher Moore, Kim Barbour
doaj   +1 more source

Global Problems in Domestic Courts [PDF]

open access: yes, 2011
We face an increasing number of problems that are essentially global in nature because they affect the world in its entirety: global cartels, climate change, crimes against humanity; to name a few. These problems require world courts, yet world courts in
Michaels, Ralf
core   +1 more source

H⁺ Exchange‐Driven ppb‐Level and High‐Selective Formaldehyde Detection at Room Temperature for Environmental and Clinical Applications

open access: yesAdvanced Science, EarlyView.
This article presents an innovative room‐temperature formaldehyde sensor based on H⁺ exchange method, achieving ppb‐level detection limit and exceptional selectivity. The study highlights its practical potential for real‐time environmental monitoring and clinical diagnostic applications.
Lubing Cai   +9 more
wiley   +1 more source

Pan‐3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits

open access: yesAdvanced Science, EarlyView.
This study firstly presents a comprehensive and high‐resolution pan‐3D genome resource in chicken. Our findings reveal the role of structural variations in 3D genome architectures, and how they influence the domestication process and production traits at the 3D genome level.
Zhen Zhou   +19 more
wiley   +1 more source

An econometric analysis of the link between biodiesel demand and Malaysian palm oil market [PDF]

open access: yes, 2011
The objective of this study is to describe the important factors affecting Malaysian palm oil industry especially biodiesel demand. To that end a market model representing palm oil production, import, world excess demand, domestic consumption, export ...
Abdel Hameed, Amna Awad   +3 more
core   +1 more source

Systematically Engineering for Efficient Production of 3‐Methyl‐1‐Butanol in Escherichia coli

open access: yesAdvanced Science, EarlyView.
An integrated metabolic engineering strategy was established for high‐level 3‐methyl‐1‐butanol biosynthesis in Escherichia coli. Molecular dynamics‐guided semi‐rational engineering of dihydroxyacid dehydratase uncovered and relieved key catalytic bottlenecks, while adaptive laboratory evolution enhanced strain robustness.
Nanfei Geng   +6 more
wiley   +1 more source

Polyoxometalate as Hydrogen–Electron Hub in Metal–Organic Complex for Electrocatalytic Nitrate Reduction to Ammonia

open access: yesAdvanced Science, EarlyView.
To tackle low electrocatalytic nitrate reduction to ammonia efficiency in neutral media, this work designs chain‐like dinuclear/trinuclear polyoxometalate‐based metal‐organic complexes. Metal clusters provide nitrate adsorption/activation sites, while polyoxometalates (POMs) drive water dissociation to generate active hydrogen (*H) that migrates to ...
Qiushuang Jiang   +5 more
wiley   +1 more source

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