Results 61 to 70 of about 10,214 (256)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Traitement antalgique des crises vaso-occlusives a domicile avant l´arrivee en consultation

The Pan African Medical Journal, 2020
INTRODUCTION: Les crises vaso-occlusives (CVO) constituent le principal motif de consultation et d’hospitalisation chez les enfants drépanocytaires et nécessite le plus souvent une prise en charge à domicile avant l’arrivée en consultation.
Alima Yanda Anastasie Nicole, Eposse Ekoube Charlotte, Ngatsing Christelle Shanti, Mandeng Ma Linwa Edgar, Françoise Ngnedjou Nwabufor Foute, Ngou Patrick, Mbono Ritha, Djike Puepi Yolande, Epee Patricia, Wete Estelle, Koki Ndombo Paul Olivier   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Urinary incontinence is common among people attending pulmonary rehabilitation, yet pulmonary rehabilitation has a small effect on urinary symptoms: A multicenter prospective cohort study

Pulmonology
Introduction Urinary incontinence (UI) is common among individuals with chronic respiratory diseases (CRDs) and may limit attendance, completion, and response to pulmonary rehabilitation (PR).
Francis-Edouard Gravier, Yann Combret, Damien Parrot, Fanny Laporte, Léna Bocquet, Pauline Smondack, Jean-François Muir, Antoine Cuvelier, Fairuz Boujibar, Arnaud Nze Ossima, Clément Médrinal, Guillaume Prieur, Tristan Bonnevie   +12 more
doaj   +1 more source

Change of Domicile [PDF]

BMJ Supportive & Palliative Care, 2014
By Clive James (1939-) > > Installed in my last house, I face the thought > > > > That fairly soon there will be one house more, > > > > Lacking the pictures and the books that here > > > > Surround me with abundant evidence > > > > I spent a lifetime pampering my mind. > > > > The new place will be …
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Revue de presse club des jeunes néphrologues (CJN) : 4e trimestre 2019 de la Dialyse à Domicile

Bulletin de la Dialyse à Domicile, 2019
Introduction (NDLR) Un groupe de néphrologues issus du Club des jeunes Néphrologues sélectionne chaque mois à tour de rôle un article de la littérature internationale en rapport avec la dialyse à domicile, Dialyse Péritonéale ou Hémodialyse à Domicile,
Julie Morinière Beaume, Céline Nodimar, Guillaume Seret, Laurence Vrigneaud, Stanislas Bataille, Odette Carceles, Morgane Gosselin, Frederic Lavainne   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source