Results 151 to 160 of about 143,721 (202)
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Crop Science, 2003
Many public sector maize recurrent selection programs have been designed based on additive genetic expectations. Populations have been managed as large metapopulations with the assumption that population size must be very large because inbreeding due to finite size causes a linear reduction in genetic variance; we show that in BS13(S)C0 such ...
Jode W. Edwards, Kendall R. Lamkey
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Many public sector maize recurrent selection programs have been designed based on additive genetic expectations. Populations have been managed as large metapopulations with the assumption that population size must be very large because inbreeding due to finite size causes a linear reduction in genetic variance; we show that in BS13(S)C0 such ...
Jode W. Edwards, Kendall R. Lamkey
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The genetics of autosomal dominant familial hypercholesterolemia
Journal of the American Association of Nurse Practitioners, 2023ABSTRACT Familial hypercholesterolemia (FH) is one of the most common genetic conditions. Affected individuals are unable to metabolize cholesterol due to inherited changes in the low-density lipoprotein (LDL) receptor, which impairs the ability to metabolize cholesterol, resulting in extremely high levels of cholesterol that leads to ...
Sharon Anderson, Christina Botti
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Dominant effector genetics in mammalian cells
Nature Genetics, 2001We have expressed libraries of peptides in mammalian cells to select for trans-dominant effects on intracellular signaling systems. As an example-and to reveal pharmacologically relevant points in pathways that lead to Taxol resistance-we selected for peptide motifs that confer resistance to Taxol-induced cell death.
X, Xu +14 more
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Genetic Basis of Dominant Dystonia
1997Publisher Summary Dominant dystonia is caused by mutations of the cyclohydrolase I (GCH) gene and is because of resultant partial striatal DA deficiency in the nigrostriatal DA neurons. Dopamine (DA) is synthesized from tyrosine via dopa by tyrosine hydroxylase (TH) and aromatic amino acid decarboxylase.
T. Nagatsu, H. Ichinose
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Genetic heterogeneity of autosomal dominant hypercholesterolemia
Clinical Genetics, 2007Autosomal dominant hypercholesterolemia (ADH) is characterized by isolated elevation of plasmatic low‐density lipoprotein cholesterol associated with high risk of premature cardiovascular complications. More than 1000 mutations in the LDLR gene and 9 in the APOB gene have been implicated.
M, Varret +3 more
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Dominance and recessivity in medical genetics
The American Journal of Medicine, 1958Abstract 1.1. Whenever it has been possible to study the effects of abnormal human genes in double-dose, they have been found to be much more severe than the effects in single-dose. Hence these abnormal human genes are not dominant in the original sense of the word, by which it was meant that the effects of a gene in single- and double-dose were ...
A C, ALLISON, B S, BLUMBERG
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2015
Dominant ataxias represent a clinically and genetically heterogeneous group of hereditary disorders comprising autosomal dominant spinocerebellar ataxias (ADCAs, SCAs) and episodic ataxias (EAs). From the clinical point of view, patients with ADCA exhibit a progressive cerebellar syndrome, either isolated or in combination with extra-cerebellar ...
Manto, Mario, Marmolino, Daniele
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Dominant ataxias represent a clinically and genetically heterogeneous group of hereditary disorders comprising autosomal dominant spinocerebellar ataxias (ADCAs, SCAs) and episodic ataxias (EAs). From the clinical point of view, patients with ADCA exhibit a progressive cerebellar syndrome, either isolated or in combination with extra-cerebellar ...
Manto, Mario, Marmolino, Daniele
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The genetics of dominant osteopetrosis
Drug Discovery Today: Disease Mechanisms, 2005Autosomal dominant osteopetroses (ADO) are classically divided into two types, ADOI and ADOII, which are differentiated according to the main sites of osteosclerosis localization. For ADOI this is the cranial vault and, for ADOII, the spine, pelvis and skull base.
Frattini A., Vezzoni P., Villa A.
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Molecular Genetic Analysis in Autosomal Dominant Keratoconus
Cornea, 1992Members in three generations of a family whose propositus had keratoconus were examined by biomicroscopy, with a corneoscope and a computer-assisted videophoto-keratoscope. Keratoconus was detected in eight of 15 family members with vertical transmission consistent with autosomal dominant inheritance. Affected individuals displayed variable topographic
Y S, Rabinowitz +6 more
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Non-dominated Rank based Sorting Genetic Algorithms
Fundamenta Informaticae, 2008In this paper a new concept of ranking among the solutions of the same front, along with elite preservation mechanism and ensuring diversity through the nearest neighbor method is proposed for multi-objective genetic algorithms. This algorithm is applied on a set of benchmark multi-objective test problems and the results are compared with that of NSGA-
Ghosh, Ashish, Das, Mrinal Kanti
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