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Differences in the evolutionary history of disease genes affected by dominant or recessive mutations [PDF]
BMC Genomics, 2006 Background Global analyses of human disease genes by computational methods have yielded important advances in the understanding of human diseases. Generally these studies have treated the group of disease genes uniformly, thus ignoring the type of ...
Albà M Mar +2 more
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DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle [PDF]
Scientific Reports, 2023 Each tissue has a dominant set of functional proteins required to mediate tissue-specific functions. Epigenetic modifications, transcription, and translational efficiency control tissue-dominant protein production.
Hideki Maehara +20 more
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Candidate genes in ocular dominance plasticity [PDF]
Frontiers in Neuroscience, 2012 Many studies have been devoted to the identification of genes involved in experience-dependent plasticity in the visual cortex. To discover new candidate genes, we have reexamined data from one such study on ocular dominance (OD) plasticity in recombinant inbred BXD mouse strains. We have correlated the level of plasticity with the gene expression data
Rietman, M.L. +13 more
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Mapping of leaf rust resistance genes in common wheat ‘Guinong08-6’
Semina: Ciências Agrárias, 2023 Wheat leaf rust (Puccinia triticina Eriks.), a devastating disease of wheat in the world, causes severe yield losses and therefore the development of resistant cultivars is very important.
Luhua Li +3 more
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Multiple minute digitate hyperkeratosis - a peculiar entity [PDF]
Anais Brasileiros de Dermatologia, 2015 Multiple minute digitate hyperkeratosis is a rare, non-follicular dermatosis, with fewer than 30 cases described worldwide. It can be either acquired or inherited in an autosomal dominant pattern.
Inês Coutinho +4 more
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Acta Scientiarum Polonorum: Hortorum Cultus, 2021 Bean common mosaic virus (BCMV) and bean common mosaic necrosis virus (BCMNV) are among the most economically important virus species infecting common bean.
İlyas Deligoz +2 more
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Differential Expression of -Associated Genes in Autosomal Dominant Polycystic Kidney Disease [PDF]
Genomics & Informatics, 2012 Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of multiple fluid-filled cysts that expand over time and destroy renal architecture. The proteins encoded by the PKD1 and PKD2 genes, mutations in which account for nearly
Yeon Joo Yook +9 more
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Open Life Sciences, 2021 Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is a rare autosomal-dominant genetic disorder, and mutations in the forkhead box L2 (FOXL2) gene are one of the major genetic causes.
Cheng Tianling +5 more
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Dominance from the perspective of gene–gene and gene–chemical interactions [PDF]
Genetica, 2015 In this study, we used genetic interaction (GI) and gene-chemical interaction (GCI) data to compare mutations with different dominance phenotypes. Our analysis focused primarily on Saccharomyces cerevisiae, where haploinsufficient genes (HI; genes with dominant loss-of-function mutations) were found to be participating in gene expression processes ...
Gladki, Arkadiusz +2 more
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Gene expression drives the evolution of dominance [PDF]
Nature Communications, 2017 Abstract Dominance is a fundamental concept in molecular genetics and has implications for understanding patterns of genetic variation, evolution, and complex traits. However, despite its importance, the degree of dominance in natural populations is poorly quantified.
Christian D. Huber +3 more
openaire +6 more sources