Results 181 to 190 of about 713,409 (294)

Measuring intolerance to mutation in human genetics

Nature Genetics, 2018
Zachary L. Fuller, Jeremy J. Berg, H. Mostafavi, Guy Sella, M. Przeworski   +4 more
semanticscholar   +1 more source

Validation of a Genetic Risk Score Combined with Clinical Variables for Predicting Pulmonary Fibrosis in early Rheumatoid Arthritis

Arthritis Care &Research, Accepted Article.
Objectives Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). The study aimed to externally validate a genetic risk score (GRS) and a combined risk score for predicting the risk of RA‐associated PF in an independent cohort of early‐RA patients. Methods This study utilized an inception cohort of 1118 patients
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Effects of inbreeding on balancing selection: insights from Fisher's geometric model. [PDF]

Genetics
Olito C, Connallon T.
europepmc   +1 more source

Hopfield Neural Networks for Online Constrained Parameter Estimation With Time‐Varying Dynamics and Disturbances

International Journal of Adaptive Control and Signal Processing, EarlyView.
This paper proposes two projector‐based Hopfield neural network (HNN) estimators for online, constrained parameter estimation under time‐varying data, additive disturbances, and slowly drifting physical parameters. The first is a constraint‐aware HNN that enforces linear equalities and inequalities (via slack neurons) and continuously tracks the ...
Miguel Pedro Silva
wiley   +1 more source

A gene-based model of fitness and its implications for genetic variation: genetic and inbreeding loads. [PDF]

Genetics
Johri P, Charlesworth B.
europepmc   +1 more source

Osteocytes under Mechanical Loading Regulate PC‐3 Cancer Cell–Mineral Interactions during Early‐Stage Metastasis to Bone

Advanced Biology, EarlyView.
In this study, Seaman et al. develop a co‐culture assay to examine interactions between prostate cancer cells and mineralized osteoblasts in a microfluidic platform. The authors collect conditioned media from static or flow‐stimulated osteocytes and demonstrate that mechanical loading of osteocytes regulates the growth of prostate cancer cells and ...
Kimberly Seaman, Bryan Guo, William W. Du, Burton Yang, Yu Sun, Lidan You   +5 more
wiley   +1 more source

Genomic prediction of agronomic traits in perennial ryegrass (Lolium perenne L.) and genotype x environment interactions at the limit of the species distribution. [PDF]

Theor Appl Genet
Johansen NH, Bellucci A, Hansen PB, Marum P, Amdahl H, Gylstrøm KH, Rognli OA, Kemešytė V, Brazauskas G, Greve M, Persson C, Isolahti M, Helgadóttir Á, Aavola R, Asp T, Ramstein GP.   +15 more
europepmc   +1 more source

Machine Learning Applied to High Entropy Alloys under Irradiation

Advanced Engineering Materials, EarlyView.
Designing alloys for extreme environments demands fast, trustworthy prediction. This review charts how machine learning—especially machine‐learned interatomic potentials and predictive models based on experiment‐informed datasets—captures the complexity of high‐entropy alloys in extreme environments, predicts phase formation, mechanical properties, and
Amin Esfandiarpour, Sri Tapaswi Nori, Silvia Bonfanti, Mikko Alava, Antoni Wadowski, Wenyi Huo, Łukasz Kurpaska, Michał Pecelerowicz, Jan S. Wróbel   +8 more
wiley   +1 more source

X‐Ray Computed Tomography Quantifies Primary Phases and Reveals Crack Morphology in High‐Cycle Fatigue of Aluminum Alloy EN AW‐2618A

Advanced Engineering Materials, EarlyView.
Primary phases and a fatigue crack are studied in a forged blank of an aluminum alloy using synchrotron and laboratory X‐ray computed tomography. To image the crack, the fatigue test is interrupted, and a static tensile load is applied to open the crack.
Jakob Schröder, Ying Han, Tobias Fritsch, Bardia Hejazi, Alexander Ulbricht, Birgit Skrotzki, Giovanni Bruno   +6 more
wiley   +1 more source

GWAS significance thresholds in large cohorts of European ancestry. [PDF]

Genetics
Cheruiyot EK, Yang T, McRae AF.
europepmc   +1 more source