Results 121 to 130 of about 25,757 (296)

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

open access: yesArthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova   +6 more
wiley   +1 more source

The effects of ovarian enzyme modulators on folliculogenesis and cyst development in the porcine ovary.

open access: yes, 2007
The first aim of the research conducted as part of this thesis was to investigate the expression and activities of 110HSD enzymes in porcine mural granulosa cells and COCs from small, medium and large antral follicles, as well as from ovarian cysts. Both
Sunak, N.
core  

Regulation and regulatory role of WNT signaling in potentiating FSH action during bovine dominant follicle selection.

open access: yes, 2014
Follicular development occurs in wave like patterns in monotocous species such as cattle and humans and is regulated by a complex interaction of gonadotropins with local intrafollicular regulatory molecules.
James J. Ireland (579072)   +20 more
core   +1 more source

DNA (cytosine‐5)‐methyltransferase 3A (Dnmt3a) mutations limit normal and autoreactive CD4+ T follicular helper responses and attenuate T cell‐driven joint inflammation

open access: yesArthritis &Rheumatology, Accepted Article.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased inflammatory markers. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen   +10 more
wiley   +1 more source

Evidence that fibroblast growth factor 10 plays a role in follicle selection in cattle

open access: yes, 2017
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)ACSCProcesso FAPESP: 2008/57365-2There is evidence that regulation of follicle selection in cattle involves locally produced growth factors. In the present study, we investigated the expression
Gasperin, B. G.   +14 more
core   +1 more source

Status of oncology drugs with a conditional approval: A cross‐sectional comparison of the Food and Drug Administration and Health Canada

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study looks at the status of the same drugs conditionally approved by the Food and Drug Administration and Health Canada for the same oncology indication. Methods Lists of oncology drugs with a conditional approval from the Food and Drug Administration and Health Canada were generated and drug pairs with the same indication were matched ...
Joel Lexchin
wiley   +1 more source

Embryo production and quality in dairy cattle is enhanced by manual transrectal ablation of the dominant follicle prior to superovulation [PDF]

open access: yes, 2019
The objective was to determine effects of manual transrectal ablation of the largest (dominant) ovarian follicle on days 7 or 8 of the cycle (estrus = day 0) to synchronize wave emergence before superovulation. Superovulation was performed in 167 donors,
Bolognini D   +3 more
core  

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher   +7 more
wiley   +1 more source

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