Results 111 to 120 of about 200,043 (266)

Fallowed agricultural lands dominate anthropogenic dust sources in California

Communications Earth & Environment
Air pollution remains a major problem in many parts of California, significantly impacting public health and regional climate. However, the contribution of anthropogenic dust from agricultural sources, among major pollutants in California’s semi-arid ...
Adeyemi A. Adebiyi, Md. Minhazul Kibria, John T. Abatzoglou, Paul Ginoux, Satyendra Pandey, Alexandra Heaney, Shu-Hua Chen, Akintomide A. Akinsanola   +7 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Human Impacts Dominate Global Loss of Lake Ecosystem Resilience

Geophysical Research Letters
Strengthening aquatic resilience to prevent adverse shifts is critical for preserving global freshwater biodiversity and advancing Sustainable Development Goals.
Yaoyao Han, Qi Lin, Shixin Huang, Chenliang Du, Ji Shen, Ke Zhang   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Water mass specific genes dominate the Southern Ocean microbiome

Nature Communications
The Southern Ocean (SO) plays a key role in regulating global biogeochemical cycles and climate, yet microbial genes sustaining its biological activity remain poorly characterized.
Emile Faure, Jolann Pommellec, Cyril Noel, Alexandre Cormier, Lisa-Marie Delpech, A. Murat Eren, Antonio Fernandez-Guerra, Chiara Vanni, Marion Fourquez, Marie-Noëlle Houssais, Ulysse Guyet, Corinne Da Silva, Frederick Gavory, Aude Perdereau, Karine Labadie, Patrick Wincker, Julie Poulain, Christel Hassler, Yajuan Lin, Nicolas Cassar, Loïs Maignien   +20 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Trait-like individual signatures dominate sleep EEG over insomnia-specific features

Scientific Reports
Insomnia-specific features of sleep EEG activity have remained elusive, with existing findings being inconsistent and often weak in effect. Using machine learning, we analyzed two independent electroencephalogram (EEG) datasets spanning two nights ...
Markus Kyllönen, Roy Cox, Tommi Makkonen, Risto Halonen, Lauri Parkkonen, Emil Hein, Eus J. W. Van Someren, Anu-Katriina Pesonen   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source