Results 161 to 170 of about 1,362,273 (352)

Human Impacts Dominate Global Loss of Lake Ecosystem Resilience

Geophysical Research Letters
Strengthening aquatic resilience to prevent adverse shifts is critical for preserving global freshwater biodiversity and advancing Sustainable Development Goals.
Yaoyao Han, Qi Lin, Shixin Huang, Chenliang Du, Ji Shen, Ke Zhang   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Bottom-Up Processes Dominate Early Word Recognition in Toddlers

Supplementary material of the accepted article Bottom-Up Processes Dominate Early Word Recognition in ...
Armando Quetzalcóatl Angulo-Chavira
core   +1 more source

Water mass specific genes dominate the Southern Ocean microbiome

Nature Communications
The Southern Ocean (SO) plays a key role in regulating global biogeochemical cycles and climate, yet microbial genes sustaining its biological activity remain poorly characterized.
Emile Faure, Jolann Pommellec, Cyril Noel, Alexandre Cormier, Lisa-Marie Delpech, A. Murat Eren, Antonio Fernandez-Guerra, Chiara Vanni, Marion Fourquez, Marie-Noëlle Houssais, Ulysse Guyet, Corinne Da Silva, Frederick Gavory, Aude Perdereau, Karine Labadie, Patrick Wincker, Julie Poulain, Christel Hassler, Yajuan Lin, Nicolas Cassar, Loïs Maignien   +20 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Code accompanying the paper "Kuroshio Extension and Gulf Stream dominate the Eddy Kinetic Energy intensification observed in the global ocean" published in Scientific Reports (2025)

The repository is also available on GitHub: https://github.com/bbarcelollull/Global_EKE_trends_from_altimetryThis repository contains the code used to conduct the study "Kuroshio Extension and Gulf Stream dominate the Eddy Kinetic Energy intensification ...
Barceló-Llull, Bàrbara, Roselló, Pere
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Severitas and clementia in punishing the crimen maiestatis from Principate to Dominate

, 2013
In this paper, the image of immense cruelty of emperors and their officials under the Dominate, presented with lots of details by Ammianus Marcellinus, will be discussed as an aspect of the emperors' attitude towards the law in political charges evolving
Melounová, Markéta
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source