Results 91 to 100 of about 51,346 (268)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Approximating a Minimum Dominating Set by Purification

Algorithms
A dominating set of a graph is a subset of vertices such that every vertex not in the subset has at least one neighbor within the subset. The corresponding optimization problem is known to be NP-hard.
Ernesto Parra Inza, Nodari Vakhania, José María Sigarreta Almira, José Alberto Hernández-Aguilar   +3 more
doaj   +1 more source

Isolate domination in graphs

Arab Journal of Mathematical Sciences, 2016
A set D of vertices of a graph G is called a dominating set of G if every vertex in V(G)−D is adjacent to a vertex in D. A dominating set S such that the subgraph 〈S〉 induced by S has at least one isolated vertex is called an isolate dominating set.
I. Sahul Hamid, S. Balamurugan
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dominating Set Algorithms for Wireless Sensor Networks Survivability

IEEE Access, 2018
Limited energy of the sensors is one of the key issues towards realizing a reliable wireless sensor network (WSN), which can survive under the emerging WSN applications.
Tayler Pino, Salimur Choudhury, Fadi Al-Turjman   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Enumerating Minimal Connected Dominating Sets

SIAM Journal on Discrete Mathematics
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Faisal Abu-Khzam, Henning Fernau, Benjamin Gras, Mathieu Liedloff, Kevin Mann   +4 more
openaire   +3 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Dominating Set Knapsack: Profit Optimization on Dominating Sets

In a large-scale network, we want to choose some influential nodes to make a profit by paying some cost within a limited budget so that we do not have to spend more budget on some nodes adjacent to the chosen nodes; our problem is the graph-theoretic representation of it.
openaire   +2 more sources