Results 121 to 130 of about 7,194,939 (348)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

On Relaxation of Dominant Sets

open access: yes, 2022
In a graph $G = (V,E)$, a k-ruling set $S$ is one in which all vertices $V$ \ $S$ are at most $k$ distance from $S$. Finding a minimum k-ruling set is intrinsically linked to the minimum dominating set problem and maximal independent set problem, which have been extensively studied in graph theory.
openaire   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Isolate domination in graphs

open access: yesArab Journal of Mathematical Sciences, 2016
A set D of vertices of a graph G is called a dominating set of G if every vertex in V(G)−D is adjacent to a vertex in D. A dominating set S such that the subgraph 〈S〉 induced by S has at least one isolated vertex is called an isolate dominating set.
I. Sahul Hamid, S. Balamurugan
doaj   +1 more source

Set domination in graphs

open access: yesJournal of Graph Theory, 1994
AbstractLet G = (V, E) be a connected graph. A set D ⊂ V is a set‐dominating set (sd‐set) if for every set T ⊂ V − D, there exists a nonempty set S ⊂ D such that the subgraph 〈S ∪ T〉 induced by S ∪ T is connected. The set‐domination number γs(G) of G is the minimum cardinality of a sd‐set.
Sampathkumar, E., Latha, L. P.
openaire   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Image Segmentation by Dominant Sets

open access: yesElectronic Notes in Discrete Mathematics, 2003
Abstract We develop a framework for the image segmentation problem based on a new graph-theoretic formulation of clustering. The approach is motivated by the analogies between the intuitive concept of a cluster and that of a dominant set of vertices, a novel notion that generalizes that of a maximal complete subgraph to edge-weighted graphs.
PAVAN M, PELILLO, Marcello
openaire   +2 more sources

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

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