Results 151 to 160 of about 61,219 (309)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Aplikasi Dominating Set untuk Irigasi Sawah
, 2018 One of the theories developed in graph theory is the dominating set. Dominating set is a concept of determining the minimum point on the graph with the provision of a point as dominating set to reach the point that is around it.
Mahmudah, Muhlisatul
core
Exact algorithms for dominating set
, 2011 The measure and conquer approach has proven to be a powerful tool to analyse exact algorithms for combinatorial problems like Dominating Set and Independent Set.
Hans L. Bodlaender +3 more
core +1 more source
Co-Secure Domination Number in Some Graphs
AxiomsLet G be a graph and S⊆V(G). If S is a dominating set of G, and for each vertex u∈V(G)−S, there is a neighbor of u in S, denoted by v, such that (S∖{v})∪{u} is a dominating set of G, then S is a secure dominating set (SDS) of G.
Jiatong Cui +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Outer independent global dominating set of trees and unicyclic graphs
, 2019 Let G be a graph. A set D ⊆ V(G) is a global dominating set of G if D is a dominating set of G and $\overline G$. γg(G) denotes global domination number of G.
Doost Ali Mojdeh, Mortaza Alishahi
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Connected Dominating Set & Related Problems
, 2019 Ερευνούμε δύο εκδοχές του προβλήματος του Συνδεδεμένου Κυρίαρχου Συνόλου (ΣΚΣ), τα προβλήματα του Μερικώς Συνδεδεμένου Κυρίαρχου Συνόλου (ΜΣΚΣ) και του Μπάτζετ Συνδεδεμένου Κυρίαρχου Συνόλου (ΠΣΚΣ).
Yfantis Filippos +3 more
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