Results 101 to 110 of about 151,596 (298)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
On double domination in graphs [PDF]
In a graph G, a vertex dominates itself and its neighbors. A subset S ⊆ V (G) is a double dominating set of G if S dominates every vertex of G at least twice. The minimum cardinality of a double dominating set of G is the double domination number γ×2(G).
Harant, Jochen +4 more
core +2 more sources
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Domination subdivision and domination multisubdivision numbers of graph
12 pages, 2 ...
Magda Dettlaff +2 more
openaire +5 more sources
On signed edge domination numbers of trees [PDF]
summary:The signed edge domination number of a graph is an edge variant of the signed domination number. The closed neighbourhood $N_G[e]$ of an edge $e$ in a graph $G$ is the set consisting of $e$ and of all edges having a common end vertex with $e ...
Zelinka, Bohdan
core +1 more source
The microbiome in human skin aging
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Stochastic dominance, regret dominance and regret-theoretic dominance
It is well known that stochastic dominance alone is insufficient for ensuring preferences when individuals experience regret. In this paper, we study two additional notions of dominance: (a) regret-theoretic dominance, which characterizes preferences in regret theory and (b) regret dominance, which characterizes preferences in mean-risk models with ...
Chin Hon Tan, Joseph C. Hartman
openaire +1 more source
Edge domination in graphs of cubes [PDF]
summary:The signed edge domination number and the signed total edge domination number of a graph are considered; they are variants of the domination number and the total domination number.
Zelinka, Bohdan +4 more
core +1 more source
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Dimensions of Emancipation: Rethinking Subjectivity, Domination and Temporality in Feminist Theory
“Emancipation” is one of the most opaque words in political language and political theory. It refers to the hope of overcoming all forms of domination, yet is articulated with the highly ambivalent notions of reason, progress, equality and liberty, and ...
Susanne Lettow
doaj +1 more source

