Results 131 to 140 of about 151,596 (298)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

On signed distance-$k$-domination in graphs [PDF]

, 2006
summary:The signed distance-$k$-domination number of a graph is a certain variant of the signed domination number. If $v$ is a vertex of a graph $G$, the open $k$-neighborhood of $v$, denoted by $N_k(v)$, is the set $N_k(v)=\lbrace u\mid u\ne v$ and ...
Sun, Liang, Xing, Huaming, Chen, Xuegang
core   +1 more source

On the equality of domination number and 2-domination number

Discussiones Mathematicae Graph Theory
The 2-domination number $γ_2(G)$ of a graph $G$ is the minimum cardinality of a set $ D \subseteq V(G) $ for which every vertex outside $ D $ is adjacent to at least two vertices in $ D $. Clearly, $ γ_2(G) $ cannot be smaller than the domination number $ γ(G) $.
Gülnaz Boruzanli Ekinci, Csilla Bujtás
openaire   +5 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

DOMINATION POLYNOMIALS: A BRIEF SURVEY AND ANALYSIS

, 2017
A dominating set S of a graph G of order n is a subset of the vertices of G such that every vertex is either in S or adjacent to a vertex of S. The domination polynomial of G, denoted D(G, x), is the generating polynomial for the number of dominating ...
Beaton, Iain
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Some necessary conditions for graphs with extremal connected 2-domination number [PDF]

Discrete Mathematics Letters
Piyawat Wongthongcue, Chalermpong Worawannotai   +1 more
doaj   +1 more source

Terre, seigneuries, monarchie en Castille, un parcours historiographique

L'Atelier du CRH
This article offers a historiographical survey of studies on lordship and land control in the Castilian sphere over the course of a long second twentieth century.
Antoine Roullet
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source