Results 91 to 100 of about 423,913 (277)
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Muslim Businessmen and Chinese Economics in Singkawang
Shirkah, 2019 Instead of being known as the “City of Tasbihâ€, nowadays Singkawang is either known as the “City of Amoy (Chinese girls)†or the “City of Thousand ChineseTemplesâ€.
Fachrurazi Fachrurazi +2 more
doaj +1 more source
Cosmological Inhomogeneities with Bose-Einstein Condensate Dark Matter
, 2012 We consider the growth of cosmological perturbations to the energy density of dark matter during matter domination when dark matter is a scalar field that has undergone Bose-Einstein condensation.
A. Burkert +11 more
core +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Mary Shelley Biopic (2017): A filmic discourse analysis
CINEJ Cinema JournalThis work analyzes the discourses that compound Mary Shelley biopic (2017), concerning male domination and female resistance. To do so, the specific objectives are: to verify how this domination permeates the main character with a view to publish her ...
Thanya Araujo, Lívia Fernanda Silva
doaj +1 more source
Graphical Analysis of Covering and Paired Domination in the Environment of Neutrosophic Information [PDF]
, 2021 Sami Ullah Khan +3 more
openalex +1 more source
False vacuum energy dominated inflation with large $r$ and the importance of $\kappa_s$
, 2014 We investigate to which extent and under which circumstances false vacuum energy ($V_0$) dominated slow-roll inflation is compatible with a large tensor-to-scalar ratio $r = O(0.1)$, as indicated by the recent BICEP2 measurement. With $V_0$ we refer to a
Antusch, Stefan +3 more
core +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Violence and the Imaginary: Some Reflections on and around the Occupy Movement
Im@go. A Journal of the Social Imaginary, 2014 Starting from the idea that we can distinguish between two main types of the imaginary – the retrograde imaginary and the imaginary of liberation, and following Michel Foucault’s distinction between dialectic and strategic logic, this essay seeks to ...
Bruno Gullì
doaj +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source