Results 91 to 100 of about 22,912,690 (329)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

DOMINATION AND CAPITALIST STATE

Ra Ximhai, 2018
The present constitutes a reflective analysis of the theory that for decades has described the mechanisms used by the capitalist state to exercise its domination in the world system.
Diana Morin-López
doaj  

Gender Domination in Game of Thrones: A Comprehensive Analysis

, 2023
Shashi Vats, Barkha, J Davis, M Wilson, R Johnson, S Brown, K Martin, L Anderson, A Patel, R Williams, E Rodriguez, M Gomez, L Robinson, H Garcia, P Thompson, L Smith, E Smith, T White   +17 more
openalex   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Forum on Recognition in Foreign Policy (Analysis) and (The Study of) Diplomacy [PDF]

Contexto Internacional
What if the quest for recognition, not power, rank or security, were the overriding objective of foreign policies? What if practices of recognition both empower and subjugate by fixing identities and reproducing the terms upon which agents become ...
Stefano Guzzini, Sam Okoth Opondo, Karen Smith   +2 more
doaj   +1 more source

Numerical Evaluation of the Fracture Process of 41Cr4 Steel: Analysis of Cracks Grown in a Plane Strain State Domination Based on Experimental Results [PDF]

, 2022
Marcin Graba
openalex   +1 more source

Average value of solutions of the bipartite quadratic assignment problem and linkages to domination analysis [PDF]

Operations Research Letters, 2015
A. Ćustić, Abraham P. Punnen
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Human Possibilities: The Interaction of Biology and Culture

Interdisciplinary Journal of Partnership Studies, 2015
This article briefly describes the two main strands of a new unified theory about human nature and human possibilities: cultural transformation theory and bio-culturalism.
Riane Eisler
doaj   +1 more source