Results 91 to 100 of about 17,770 (310)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Éprouver la domination. Par-delà le travail émotionnel

Tracés
The concept of emotion work developed by Arlie Hochschild has now become essential to any reflection on the sensitive experience of domination. Hochschild’s research, which uncovers a previously invisible form of exploitation based on emotional control ...
Manuel Schotté
doaj   +1 more source

O GRUPO LEMANN E O NOVO PAPEL DOS APARELHOS PRIVADOS DE HEGEMONIA NO CAMPO DA EDUCAÇÃO NO BRASIL

Revista Trabalho, Política e Sociedade, 2019
The article analyzes the performance of the Lemann Group which, through the Lemann Foundation, has been acting on several fronts of the public education policy in Brazil.
Maria Teresa Cavalcanti de Oliveira
doaj   +1 more source

Quantitative weighted estimates for Harmonic analysis operators in the Bessel setting by using sparse domination [PDF]

, 2022
Víctor Almeida, Jorge J. Betancor, Juan C. Fariña, Lourdes Rodrı́guez-Mesa   +3 more
openalex   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Bibliometric Analysis of Male Domination Articles Since 1958-2022

, 2023
Ahmad Hamidi, Nurus Shalihin, Amelia Permata Sari, Arwansyah Bin Kirin, Amelia Permata Sari, Universitas Insan Cita Indonesia (UICI), Arwansyah bin Kirin, Universiti Tun Hussein Onn Malaysia   +7 more
openalex   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Asymptotic analysis of bending-dominated shell junctions

Journal de Mathématiques Pures et Appliquées, 2005
Summary: We consider a structure made of two shells of thickness \(2\varepsilon\), having a middle surface of class \(C^3\) and bonded together on a part of their boundaries. We suppose that at every point of their intersection, the middle surfaces have distinct tangent planes.
openaire   +3 more sources