Results 91 to 100 of about 8,731,938 (294)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 2005 For a finite undirected graph G on n vertices two continuous optimization problems taken over the n-dimensional cube are presented and it is proved that their optimum values equal the domination number γ of G.
Harant, Jochen, Göring, Frank
core +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Independent [1,2]-number versus independent domination number
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2017 A [1; 2]-set S in a graph G is a vertex subset such that every vertex not in S has at least one and at most two neighbors in it. If the additional requirement that the set be independent is added, the existence of such sets is not guaranteed in every ...
Aleid Sahar A. +2 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Bounds on the exponential domination number
Discrete Mathematics, 2017 As a natural variant of domination in graphs, Dankelmann et al. [Domination with exponential decay, Discrete Math. 309 (2009) 5877-5883] introduce exponential domination, where vertices are considered to have some dominating power that decreases exponentially with the distance, and the dominated vertices have to accumulate a sufficient amount of this ...
Bessy, Stéphane +2 more
openaire +4 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
On the r-domination number of a graph
Discrete Mathematics, 1992 If \(r>0\) the \(r\)-domination number of a graph \(G_ n\) is the size \(d_ r\) of a smallest set of vertices such that every vertex of \(G\) is within distance \(r\) of a vertex in that set. The authors show, among other things, that if \(G\) has a spanning tree with at least \(n/2\) leaves then \(d_ r\leq\max\{n/(2r),1\}\).
Jerrold R. Griggs, Joan P. Hutchinson
openaire +1 more source