Results 111 to 120 of about 10,021,129 (363)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Domination Number and Secure Resolving Sets in Cyclic Networks
Applied and Computational Mathematics, 2023 Basma Mohamed, Mohamed Amin
semanticscholar +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Fair Domination Number in Cactus Graphs
Discussiones Mathematicae Graph Theory, 2019 For k ≥ 1, a k-fair dominating set (or just kFD-set) in a graph G is a dominating set S such that |N(v) ∩ S| = k for every vertex v ∈ V \ S. The k-fair domination number of G, denoted by fdk(G), is the minimum cardinality of a kFD-set.
Majid Hajian, N. J. Rad
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Forcing Independent Domination Number of a Graph
European Journal of Pure and Applied Mathematics, 2019 In this paper, we obtain the forcing independent domination number of some special graphs. Further, we determine the forcing independent domination number of graphs under some binary operations such join, corona and lexicographic product of two graphs.
C. Armada, S. Canoy
semanticscholar +1 more source
Irredundance number versus domination number
Discrete Mathematics, 1991 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Computing locating-total domination number in some rotationally symmetric graphs. [PDF]
Sci Prog, 2021 Raza H, Iqbal N, Khan H, Botmart T.
europepmc +1 more source