Results 191 to 200 of about 12,814,856 (242)

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Editorial: Exploring kidney pathology in transplantation: spotlight on non-neoplastic conditions and DCD donor quality

Frontiers in Medicine
Alessandro Del Gobbo, Nadia Mansour, Nadia Mansour, Alessandra Maria Storaci, Alessandra Maria Storaci   +4 more
doaj   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Potential missed opportunities for organ donation: incidence and risk factors for non-referral among critically ill patients. [PDF]

Front Transplant
Nobile L, Faso C, Furlan G, Annoni F, Labbé V, Mezidi M, Lucidi V, Gustot T, Vincent JL, Taccone FS.   +9 more
europepmc   +1 more source

MicroRNA‐941 Acts as a Novel Prognostic Predictor and Oncogenic Driver in Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
Upregulation of miR‐941 was a promising diagnostic and prognostic biomarker for CRC patients. Inhibition of miR‐941 significantly suppressed CRC cellular events and triggered ferroptosis. The oncogenic functions of miR‐941 were mediated through targeting TRPS1.
Hong Li, Yang Liu, Hua Chen, Jialin Li, Xinchun Li, Yanmin Chen   +5 more
wiley   +1 more source

Rapid Diagnosis and Surgical Management of Catastrophic Stanford Type A Acute Aortic Dissection Resulting in Successful Lung Donation: A Case Report. [PDF]

Clin Case Rep
Yokawa K, Abe R, Higuma T, Yoshida K, Obo H, Kadotani M, Wakiyama H.   +6 more
europepmc   +1 more source

Prediction of Long‐Term Prognosis in Patients With Hepatocellular Carcinoma Using the National Clinical Database Risk Calculator

Annals of Gastroenterological Surgery, EarlyView.
This study aimed to determine the value of the National Clinical Database (NCD) risk calculator in predicting surgical outcomes and long‐term prognosis in patients undergoing resection for hepatocellular carcinoma (HCC). We retrospectively analyzed data from 210 patients with HCC who underwent initial hepatic resection, assessing the relationship ...
Mariko Tsukagoshi, Kenichiro Araki, Norio Kubo, Takamichi Igarashi, Shunsuke Kawai, Kei Hagiwara, Kouki Hoshino, Ryo Muranushi, Ken Shirabe   +8 more
wiley   +1 more source

Acceptance of Organs From Deceased Donors: Results of a Global Survey. [PDF]

Transplant Direct
Cantarovich M, Askar M, Sandal S, Meshram HS, Beed S, Dwyer KM, Krishnan N, Ghnaimat M, Kute VB, Diaz C, Abbud-Filho M, Ahn C, Tan BH, Garcia-Padilla P, Imventarza O, Ha J, Egawa H, Ferreira GF, Elenjickal EJ, Pilmore H, Bušic M, Schiff J, Manyalich M, Danziger-Isakov L, Berenguer M, Domínguez-Gil González B, Gill J, Tchervenkov J, Hawthorne WJ, Markmann J, Stock P, Dhital K, Zuckerman A, Herrera-Gayol A, Gondolesi GE, TTS Access to Transplantation Working Group and the representatives of the participating national, regional, and international societies/organizations, TTS Access to Transplantation Working Group and the representatives of the participating national, regional, and international societies/organizations .   +40 more
europepmc   +1 more source

Preoperative FIB‐4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
This study demonstrates that a preoperative FIB‐4 index ≥ 5.0 independently predicts severe complications and endogenous organ failure (EOF) following hepatectomy for hepatocellular carcinoma. By capturing structural liver fragility and systemic vulnerability, the FIB‐4 index enhances surgical risk stratification beyond traditional functional markers ...
Masanori Nakamura, Yukiyasu Okamura, Osamu Aramaki, Nao Yoshida, Yusuke Mitsuka, Hayato Abe, Shunsuke Yamagishi, Yasuhiro Okumura, Kyongsun Pak, Shinobu Masuda   +9 more
wiley   +1 more source