Results 121 to 130 of about 12,409,454 (287)

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke

Advanced Healthcare Materials, EarlyView.
Preparation of RVG‐modified erythrocyte membrane‐coated HMPB nanocarriers loaded with L‐arginine and NBP (RM@HPAN) and its neuroprotective mechanism. After intravenous injection, RM@HPAN achieves prolonged circulation, RVG‐29‐mediated BBB penetration, and ischemic accumulation.
Shaofa Li, Ying Wu, Huimin Wei, Jinyong Teng, Zaizhi Yang, Jufang Chen, Bao Liao, Xiaoqin Huang, Lanqing Meng, Tong Li   +9 more
wiley   +1 more source

Kidney transplant from donation after circulatory death: a novel pre-transplant combined clinico-pathological predictive score

Background: Kidney donation after circulatory death is a valid alternative to donation after brain death. However, ischemia–reperfusion injury can damage the graft and make it non-viable.
Mansour N, Gianelli U, Ferrero S, Del Gobbo A, Bizzo L, Rossi MC, Storaci AM, De Feo T   +7 more
core   +1 more source

Optimization of pretransplant amiodarone therapy to prevent primary graft dysfunction following heart transplantation

JHLT Open
Background: Despite its side effects, amiodarone remains widely used for arrhythmias in patients awaiting heart transplantation (HT). We evaluated the impact of pretransplant amiodarone use and the timing of its discontinuation on the risk of primary ...
Ye In Christopher Kwon, BA, Michael Keller, BS, Alan Lai, BS, Matthew Ambrosio, MS, Jay Patel, MD, Kelli Fox, DO, Inna F. Tchoukina, MD, Keyur B. Shah, MD, Zachary Fitch, MD, Josue Chery, MD, Mohammed Quader, MD, Patricia Nicolato, DO, Vigneshwar Kasirajan, MD, Zubair A. Hashmi, MD   +13 more
doaj   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Heart Transplant: Donation after Circulatory Death [PDF]

, 2019
Donation after circulatory death (DCD) is a potential avenue to narrow the gap between demand for donor hearts and their limited supply. DCD was abandoned after 1970 where donation of organs after brain death became the standard, however DCD has made a ...
Hasan, Saifullah, Bhamidipati, Castigliano   +1 more
core   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source

The Circulatory-Respiratory Determination of Death in Organ Donation

, 2010
OBJECTIVE: Death statutes permit physicians to declare death on the basis of irreversible cessation of circulatory-respiratory or brain functions. The growing practice of organ donation after circulatory determination of death now requires physicians to ...
Bleck, Thomas P., Nakagawa, Thomas A., Shemie, Sam D., Rushton, Cynda Hylton, DeVita, Michael A., Childress, James F., Bratton, Susan L., Mathur, Mudit, White, Douglas B., Bernat, James L., Capron, Alexander M., Blosser, Sandralee, Gries, Cynthia J., Fulda, Gerard J.   +13 more
core   +1 more source

Donation after circulatory death with thoracoabdominal normothermic regional perfusion recovery has similar outcomes with donation after brain death for lung transplantation

JHLT Open
Introduction: Donation after circulatory death (DCD) with thoracoabdominal normothermic regional perfusion (TA-NRP) has been increasingly used to procure cardiac allografts; however, concerns persist regarding its impact on lung allografts.
Sarah Y. Park, MD, Emily Hay-Arthur, BA, Elizabeth J. Bashian, MD, Han Le, MS, Michal Schäfer, MD, PhD, David N. Campbell, MD, Nicholas R. Teman, MD, Alice L. Gray, MD, Jordan R.H. Hoffman, MD, MPH, Michael T. Cain, MD   +9 more
doaj   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source