Results 171 to 180 of about 276,302 (380)

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Bioactive Compounds Protect Mammalian Reproductive Cells from Xenobiotics and Heat Stress-Induced Oxidative Distress via Nrf2 Signaling Activation: A Narrative Review

Antioxidants
Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and the body’s antioxidant defenses. It poses a significant threat to the physiological function of reproductive cells. Factors such as xenobiotics
Muhammad Zahoor Khan, Adnan Khan, Bingjian Huang, Ren Wei, Xiyan Kou, Xinrui Wang, Wenting Chen, Liangliang Li, Muhammad Zahoor, Changfa Wang   +9 more
doaj   +1 more source

Bioprinting of Microtissues Within Mechanically Tunable Support Baths to Engineer Anisotropic Musculoskeletal Tissues

Advanced Science, EarlyView.
This study presents a novel 4D bioprinting platform for engineering biomimetic musculoskeletal grafts. By tuning the mechanical properties of support baths, we enhance tissue fusion, collagen alignment, and cell differentiation. Using this strategy, we successfully fabricate scaled‐up, anisotropic tissues such as meniscus, articular cartilage, and ...
Francesca D. Spagnuolo, Gabriela S. Kronemberger, Daniel J. Kelly   +2 more
wiley   +1 more source

Besnoitiosis in donkeys: an emerging parasitic disease of equids in Italy [PDF]

, 2021
Luca Villa, Alessia Libera Gazzonis, Carlos Diezma‐Díaz, Chiara Perlotti, Sergio Aurelio Zanzani, Francesco Ferrucci, Gema Álvarez‐García, Maria Teresa Manfredi   +7 more
openalex   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

Travels with a Donkey: further adventures in social research [PDF]

, 2009
Alvesson M., Anne Pirries, Arendt H., Bennett A., Bourdieu P., Bourdieu P., Fuller S., Gale Macleod, Ingold T., Klee P., Murdoch I., Orwell G., Sennett R., Sennett R., Stevenson R.L., Stevenson R.L., Weil S., Weil S.   +17 more
core   +1 more source

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

New simplified protocols for timed artificial insemination (TAI) in milk-producing donkeys

, 2019
Diana Fanelli, M Tesi, G. Bagnato, Federica Salari, Mina Martini, Duccio Panzani, Francesco Camillo, Alessandra Rota   +7 more
openalex   +2 more sources

Chronic tuberculosis caused by Mycobacterium bovis in a domestic donkey in Central Europe [PDF]

, 2022
Natalia Siwińska, Agnieszka Żak, Malwina Słowikowska, А. Niedźwiedź, R. Ciaputa, I. Janus, Marek Lipiec, Łukasz Radulski, Adam Szymerowski, Marcin Nowak   +9 more
openalex   +1 more source

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source