Results 241 to 250 of about 247,608 (349)

Spatial Transcriptomic Analysis Reveals HDAC Inhibition Modulates Microglial Dynamics to Protect Against Ischemic Stroke in Mice

Glia, EarlyView.
Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses ...
Kevin Jayaraj, Ritesh Kumar, Sukanya Shyamasundar, Thiruma V. Arumugam, Jai S. Polepalli, S. Thameem Dheen   +5 more
wiley   +1 more source

Comparative Testis Morphometry and Seminiferous Epithelium Cycle Length in Donkeys and Mules1

, 2002
Elizabeth S. Neves, Hélio Chiarini‐Garcia, Luiz R. França   +2 more
openalex   +1 more source

Mapping Glial Autophagy Dynamics in an Amyotrophic Lateral Sclerosis Mouse Model Reveals Microglia and Astrocyte Autophagy Dysfunction

Glia, EarlyView.
In SOD1 mice, symptomatic spinal microglia and astrocytes show increased autophagy flux with greater dysfunction and SOD1 inclusions in astrocytes. Dysfunction was transient (end stage glia displayed control comparable levels of autophagy parameters). ABSTRACT Amyotrophic lateral sclerosis (ALS) is defined by motor neuron death.
Nirma D. Perera, Subhavi De Silva, Doris Tomas, Brittany Cuic, Bradley J. Turner   +4 more
wiley   +1 more source

Comprehensive analysis of species-specific differences in fatty acid composition and proteome of milk fat globules in human and animals. [PDF]

Food Chem X
Ji Z, Meng L, Sun X, Han R, Yang Y, Wang J, Zheng N.   +6 more
europepmc   +1 more source

Drebrin Upregulation Regulates Astrocyte Polarization and Supports Tissue Recovery After Spinal Cord Injury in Mice

Glia, EarlyView.
ABSTRACT Spinal cord injury (SCI) results in significant disruption of nerve fibers responsible for transmitting signals between the brain and body, often leading to partial or complete motor, sensory, and autonomic dysfunction below the injury site. Astrocytes are an important component in scar formation, crucial for suppression of injury propagation,
Barbora Smejkalová, Marta Ornaghi, Kateřina Štěpánková, Juliane Schiweck, Lucia Machová Urdzíková, Robert Huelse, Susanne Mueller, Philipp Boehm‐Sturm, Jessica C. F. Kwok, James Fawcett, Kai Murk, Britta J. Eickholt, Pavla Jendelová   +12 more
wiley   +1 more source

Milk Yield, Major Milk Components and Macro Minerals in Blood Serum of Lactating Donkeys, as Affected by Dietary Trace Element Supplementation and Stage of Lactation. [PDF]

Animals (Basel)
Fantuz F, Todini L, Salimei E, Fatica A, Mariani P, Marcantoni F, Ferraro S.   +6 more
europepmc   +1 more source

Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer

Head &Neck, EarlyView.
ABSTRACT Background Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with a 20% recurrence rate. Bitter taste receptors (T2Rs) and their genes (TAS2Rs) may regulate survival in solid tumors. This study examined T2R expression and function in PTC cells.
Kimberly Wei, Brianna L. Hill, Joel C. Thompson, Zoey A. Miller, Arielle Mueller, Robert J. Lee, Ryan M. Carey   +6 more
wiley   +1 more source

Stoicism or Defeat? The Psychological Impact of the Kiln Environment on Working Donkeys and Mules. [PDF]

Animals (Basel)
Taylor K, Harrison A, Capaldo T.
europepmc   +1 more source

Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin

International Journal of Cancer, EarlyView.
What's New? Integrins are critical mediators of cell adhesion and migration and have been implicated in cancer progression. Here, the authors show that endothelial cells in target organs of colorectal cancer metastasis express fibronectin, and that colorectal cancer tumour cells can bind fibronectin through integrin β6. This interaction is resistant to
Chiara Van Passen, Julia Krug, Luisa Weiß, Mariam Mohamed Abdou, Philipp Tripal, Benjamin Schmid, René Krüger, Yanmin Lyu, Bisan Abdalfatah Zohud, Katja Petter, Carol Geppert, Susanne Merkel, Barbara Bärthlein, Philipp Busenhart, Michael Scharl, Elisabeth Naschberger, Michael Stürzl   +16 more
wiley   +1 more source

Redox profiling of preovulatory follicular fluid in the donkey is species-specific, and contributes to modulate sperm function. [PDF]

Sci Rep
Catalán J, Padilla L, Maside C, Martínez-Hernández J, Yánez-Ortiz I, Tvarijonaviciute A, Barranco I, Bonet S, Miró J, Yeste M.   +9 more
europepmc   +1 more source